Author

Graham K. Darby

Observed names: Dr Graham Darby, G Darby, G K Darby, G. Darby, G. K. DARBY, G. K. Darby, GRAHAM DARBY, Graham Darby

Observed institutions: University of North Carolina at Chapel Hill, California Institute of Technology, Pace University, GlaxoSmithKline (United Kingdom), University of Cambridge, Addenbrooke's Hospital, University of Birmingham, Wellcome Trust

OpenAlex ID: A5111985188

HIV with Reduced Sensitivity to Zidovudine (AZT) Isolated During Prolonged Therapy

1989 · Bredan A. Larder, Graham Darby, et al. · Science · 1,568

High resolution structures of HIV-1 RT from four RT–inhibitor complexes

1995 · Jingshan Ren, Robert Esnouf, et al. · Nature Structural & Molecular Biology · 504

Human Immunodeficiency Virus

1996 · Barbara Maschera, Graham Darby, et al. · Journal of Biological Chemistry · 386

Ordered Appearance of Zidovudine Resistance Mutations during Treatment of 18 Human Immunodeficiency Virus-Positive Subjects

1992 · C. A. B. Boucher, E. O'Sullivan, et al. · The Journal of Infectious Diseases · 353

Site-specific mutagenesis of AIDS virus reverse transcriptase

1987 · Brendan A. Larder, Dorothy J. M. Purifoy, et al. · Nature · 313

1987 · B.A. Larder, S.D. Kemp, et al. · The EMBO Journal · 244

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Pathogenicity in mice of strains of herpes simplex virus which are resistant to acyclovir in vitro and in vivo

1980 · H J Field, G Darby · Antimicrobial Agents and Chemotherapy · 241

The Role of Herpes Simplex Virus Type 1 Thymidine Kinase in Pathogenesis

1989 · S. Efstathiou, S. Kemp, et al. · Journal of General Virology · 231

Survey of Resistance of Herpes Simplex Virus to Acyclovir in Northwest England

1998 · Jacqueline Christophers, Julie Clayton, et al. · Antimicrobial Agents and Chemotherapy · 208

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Altered substrate specificity of herpes simplex virus thymidine kinase confers acyclovir-resistance

1981 · G. Darby, H. J. Field, et al. · Nature · 204

Protein Crystal Growth in Microgravity

1989 · Lawrence J. DeLucas, Craig D. Smith, et al. · Science · 191

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Zidovudine sensitivity of human immunodeficiency viruses from high-risk, symptom-free individuals during therapy

1990 · C.A.B. Boucher, J.M.A. Lange, et al. · The Lancet · 179

Isolation and Characterization of Acyclovir-resistant Mutants of Herpes Simplex Virus

1980 · H. J. Field, G. Darby, et al. · Journal of General Virology · 152

HIV-1 reverse transcriptase: crystallization and analysis of domain structure by limited proteolysis

1988 · Denise M. Lowe, Alastair Aitken, et al. · Biochemistry · 148

Herpes Simplex Virus Latency: the Cellular Location of Virus in Dorsal Root Ganglia and the Fate of the Infected Cell Following Virus Activation

1980 · J. L. McLennan, G. Darby · Journal of General Virology · 145

Evidence that the 'Active Centre' of the Herpes Simplex Virus Thymidine Kinase Involves an Interaction between Three Distinct Regions of the Polypeptide

1986 · G. Darby, B. A. Larder, et al. · Journal of General Virology · 144

Predicting and preventing the emergence of antiviral drug resistance in HSV-2

1998 · S.M. Blower, T.C. Porco, et al. · Nature Medicine · 128

AIDS virus reverse transcriptase defined by high level expression in Escherichia coli.

1987 · B. Larder, D. Purifoy, et al. · The EMBO Journal · 124

Virus drug-resistance: mechanisms and consequences

1984 · Brendan A. Larder, Graham Darby · Antiviral Research · 107

Characterization of a DNA Polymerase Mutant of Herpes Simplex Virus from a Severely Immunocompromised Patient Receiving Acyclovir

1989 · P. Collins, B. A. Larder, et al. · Journal of General Virology · 102

Fifty Years of Antimicrobials: Past Perspectives and Future Trends.

1996 · P. A. Hunter, G. K. Darby, et al. · Journal of Eukaryotic Microbiology · 93

Characterization of Abnormal Thymidine Kinases Induced by Drug-resistant Strains of Herpes Simplex Virus Type 1

1983 · B. A. Larder, Y.-C. Cheng, et al. · Journal of General Virology · 92

Characterization of human immunodeficiency virus type 1 reverse transcriptase by using monoclonal antibodies: role of the C terminus in antibody reactivity and enzyme function

1988 · M Tisdale, P Ertl, et al. · Journal of Virology · 90

Introduction of the herpes simplex virus thymidine kinase gene into mouse cells using virus DNA or transformed cell DNA

1978 · A.C. Minson, P. Wildy, et al. · Cell · 81

Specificity of the Immune Response of Mice to Herpes Simplex Virus Glycoproteins B and D Constitutively Expressed on L Cell Lines

1987 · B. A. Blacklaws, A. A. Nash, et al. · Journal of General Virology · 80

Works count: 96

Citation count: 7,481

H-index: 39

I10-index: 63