Author

Jürgen Wichmann

Observed names: J WICHMANN, J Wichmann, J. WICHMANN, J. Wichmann, Jurgen Wichmann, Wichmann, J.

Observed institutions: F. Hoffmann-La Roche AG, National Institute on Drug Abuse, University of Basel, University of Michigan, Michigan Medicine, National Institute on Alcohol Abuse and Alcoholism, Boehringer Ingelheim (Canada), University of Göttingen

ORCID: 0009-0009-3676-9720

Observed ORCID: 0009-0009-3676-9720

OpenAlex ID: A5113440329

5-HT2C Receptor Agonists: Pharmacological Characteristics and Therapeutic Potential

1998 · J.R. Martin, M. Bös, et al. · Journal of Pharmacology and Experimental Therapeutics · 335

Fenobam: A Clinically Validated Nonbenzodiazepine Anxiolytic Is a Potent, Selective, and Noncompetitive mGlu5 Receptor Antagonist with Inverse Agonist Activity

2005 · Richard H.P. Porter, Georg Jaeschke, et al. · Journal of Pharmacology and Experimental Therapeutics · 308

Positive allosteric modulators of metabotropic glutamate 1 receptor: Characterization, mechanism of action, and binding site

2001 · Frédéric Knoflach, Vincent Mutel, et al. · Proceedings of the National Academy of Sciences · 239

5HT2C receptor agonists exhibit antidepressant-like properties in the anhedonia model of depression in rats

1996 · J.-L. Moreau, M. Bös, et al. · European Neuropsychopharmacology · 122

Synthesis of (1S,3aS)-8-(2,3,3a,4,5,6-hexahydro-1H-phenalen-1-yl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one, a potent and selective orphanin FQ (OFQ) receptor agonist with anxiolytic-like properties

2000 · J Wichmann · European Journal of Medicinal Chemistry · 108

Pharmacological Characterization of the Novel Nonpeptide Orphanin FQ/Nociceptin Receptor Agonist Ro 64-6198: Rapid and Reversible Desensitization of the ORL1 Receptor in Vitro and Lack of Tolerance in Vivo

2001 · Frank M. Dautzenberg, Jürgen Wichmann, et al. · Journal of Pharmacology and Experimental Therapeutics · 99

9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers

2005 · Eric Vieira, Jörg Huwyler, et al. · Bioorganic & Medicinal Chemistry Letters · 98

Behavioral Effects of a Synthetic Agonist Selective for Nociceptin/Orphanin FQ Peptide Receptors in Monkeys

2009 · Mei-Chuan Ko, James H Woods, et al. · Neuropsychopharmacology · 97

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An investigation of the role of 5-HT2C receptors in modifying ethanol self-administration behaviour

2002 · Denise M Tomkins, N Joharchi, et al. · Pharmacology Biochemistry and Behavior · 97

Novel Agonists of 5HT 2C Receptors. Synthesis and Biological Evaluation of Substituted 2-(Indol-1-yl)-1-methylethylamines and 2-(Indeno[1,2- b ]pyrrol-1-yl)-1-methylethylamines. Improved Therapeutics for Obsessive Compulsive Disorder

1997 · Michael Bös, François Jenck, et al. · Journal of Medicinal Chemistry · 97

High-Affinity, Non-Peptide Agonists for the ORL1 (Orphanin FQ/Nociceptin) Receptor

2000 · Stephan Röver, Geo Adam, et al. · Journal of Medicinal Chemistry · 83

Characterization of [3H]‐(2S,2′R,3′R)‐2‐(2′,3′‐dicarboxy‐ cyclopropyl)glycine ([3H]‐DCG IV) binding to metabotropic mGlu2 receptor‐transfected cell membranes

1998 · Jayne Cartmell, Geo Adam, et al. · British Journal of Pharmacology · 83

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Characterization of [3H]-LY354740 binding to rat mGlu2 and mGlu3 receptors expressed in CHO cells using Semliki Forest virus vectors

2000 · Christophe Schweitzer, Claudia Kratzeisen, et al. · Neuropharmacology · 81

The effect of a systemically active ORL-1 agonist, Ro 64-6198, on the acquisition, expression, extinction, and reinstatement of morphine conditioned place preference

2005 · J SHOBLOCK, J WICHMANN, et al. · Neuropharmacology · 80

A combined pharmacological and genetic approach to investigate the role of orphanin FQ in learning and memory

2002 · G. A. Higgins, J. N. C. Kew, et al. · European Journal of Neuroscience · 79

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Orphanin FQ/nociceptin but not Ro 65-6570 inhibits the expression of cocaine-induced conditioned place preference

2002 · J. Kotlińska, J. Wichmann, et al. · Behavioural Pharmacology · 78

Structure-activity relationships of substituted 5H-thiazolo[3,2-a]pyrimidines as group 2 metabotropic glutamate receptor antagonists

1999 · Jürgen Wichmann, Geo Adam, et al. · Bioorganic & Medicinal Chemistry Letters · 78

Influence of the selective ORL1 receptor agonist, Ro64-6198, on rodent neurological function

2001 · G.A Higgins, A.J Grottick, et al. · Neuropharmacology · 71

Nociceptin Receptor Impairs Recognition Memory via Interaction with NMDA Receptor-Dependent Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Signaling in the Hippocampus

2008 · Celia Goeldner, David Reiss, et al. · Journal of Neuroscience · 70

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Antiaversive effects of 5HT2C receptor agonists and fluoxetine in a model of panic-like anxiety in rats

1998 · François Jenck, Jean-Luc Moreau, et al. · European Neuropsychopharmacology · 68

The role of 5ht2c receptors in affective disorders

1998 · F Jenck, M Bös, et al. · Expert Opinion on Investigational Drugs · 67

Metabotropic Glutamate Receptor 5 Negative Allosteric Modulators: Discovery of 2-Chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1 H -imidazol-4-ylethynyl]pyridine (Basimglurant, RO4917523), a Promising Novel Medicine for Psychiatric Diseases

2015 · Georg Jaeschke, Sabine Kolczewski, et al. · Journal of Medicinal Chemistry · 66

8-Acenaphthen-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one derivatives as orphanin FQ receptor agonists

1999 · Jürgen Wichmann, Geo Adam, et al. · Bioorganic & Medicinal Chemistry Letters · 64

Effects of the mGluR2/3 agonist LY354740 on computerized tasks of attention and working memory in marmoset monkeys

2005 · Simona Spinelli, Theresa Ballard, et al. · Psychopharmacology · 57

Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators

2011 · L Lundström, C Bissantz, et al. · British Journal of Pharmacology · 54

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Works count: 117

Citation count: 3,653

H-index: 33

I10-index: 65