Author

Newell

Observed names: D R Newell, David Newell

Observed institution: Newcastle University

OpenAlex ID: A5113512770

Recent preclinical and clinical studies with the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid (CB3717)

1987 · Alan Calvert, David Newell, et al. · PubMed · 29

Pharmacokinetics of the thymidylate synthase inhibitor N10-propargyl-5,8-dideazafolic acid (CB3717) in the mouse.

1986 · D R Newell, D L Alison, et al. · PubMed · 25

Final clinical, pharmacokinetic and pharmacodynamic results of the phase I study of the novel poly(ADP-ribose)polymerase (PARP) inhibitor, AG014699, in combination with temozolomide

2005 · Elizabeth Plummer, M Middleton, et al. · Newcastle University ePrints (Newcastle Univesity) · 7

Structural and thermodynamic validation of inactive cdk2 as a template for structure-based drug design

2001 · TG Davies, JA Endicott, et al. · Newcastle University ePrints (Newcastle Univesity) · 2

Design and evaluation of novel potent inhibitors of poly (ADP-ribose) polymerase

2000 · CR Calabrese, Nicola Curtin, et al. · UCL Discovery (University College London) · 2

Validation of pharmacologically-guided dosing of carboplatin in paediatric patients

1998 · Huw Thomas, AV Boddy, et al. · Newcastle University ePrints (Newcastle Univesity) · 2

Dipyridamole Induced-inhibition of Thymidine Incorporation Invivo and Potentiation of Cb3717 Cyto-toxicity Invitro

1985 · Newell, Pm Oconnor, et al. · British Journal of Cancer · 2

Pharmacokinetic Studies in Humans With Cb3717 (n-(4-(2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-l-glutamic Acid)

1983 · Dl Alison, Newell, et al. · UCL Discovery (University College London) · 2

Antiproliferative cyclin dependent kinase inhibitors with distinct molecular interactions and tumor cell growth inhibition profiles.

1999 · Newell, CE Arris, et al. · UCL Discovery (University College London) · 1

Biochemical Disturbances Observed Invitro and Invivo Following Inhibition of Thymidylate Synthetase by C-3717

1982 · A.L. Jackman, G. C. Taylor, et al. · UCL Discovery (University College London) · 1

Inhibition of DNA-Repair Enzymes (DNA-Pk and Parp) to Sensitize Ewing Sarcoma to Chemo-And Radiotherapy

2015 · B. Vormoor, Y. Schlosser, et al. · PubMed Central

Design and synthesis of dual CDK2 and CDK7 inhibitors

2010 · Elisa Meschini, Jane Endicott, et al. · Newcastle University ePrints (Newcastle Univesity)

Development of potent inhibitors of DNA-dependent protein kinase (DNA-PK)

2010 · KM Clapham, Tommy Rennison, et al.

MEDI 147-Isoindolinone-based inhibitors of the MDM2-p53 protein-protein interaction

2008 · Eric Valeur, IR Hardcastle, et al.

Identification of MYCN transcriptional activity inhibitors yields compounds which preferentially inhibit the growth of neuroblastoma cells

2004 · X Lu, David Newell, et al. · Newcastle University ePrints (Newcastle Univesity)

Anti-cancer chemosensitization in vitro and in vivo by a novel potent poly(ADP-ribose) polymerase (PARP1) inhibitor, TBI-361.

2001 · Nicola Curtin, Stephen Barton, et al. · UCL Discovery (University College London)

Structure-activity relationships and cellular effects of novel purine- and pyrimidine-based cyclin dependent kinase inhibitors

2000 · J Bentley, CE Arris, et al. · UCL Discovery (University College London)

Chemopotentiation studies with two classes of potent (polyADP-ribose) polymerase (PARP) inhibitors in human lung and colon carcinoma cell lines.

2000 · Nicola Curtin, Alan Calvert, et al. · UCL Discovery (University College London)

Design, synthesis, and biological evaluation of O-6-alkylguanine and O-4-alkylpyrimidine cyclin-dependent kinase inhibitors

2000 · RJ Griffin, CE Arris, et al. · UCL Discovery (University College London)

In vitro/in vivo correlations of cisplatin-DNA adduct levels in leucocytes of children

2000 · Gareth Veal, C Dias, et al. · Newcastle University ePrints (Newcastle Univesity)

In vitro activity and in vivo pharmacology of two novel nucleoside transport inhibitors, NU3108 and NU3121

2000 · P G Smith, HD Thomas, et al. · UCL Discovery (University College London)

Preclinical pharmacology of novel substituted benzimidazoles - potent inhibitors of poly (ADP-ribose) polymerase

1999 · CR Calabrese, Huw Thomas, et al. · UCL Discovery (University College London)

2,6-Disubstituted-4,8-dibenzylaminopyrimido[5,4-d]pyrimidines as nucleoside transport inhibitors: Structure-activity relationships for binding to alpha(1)-acid glycoprotein (AGP)

1999 · Griffin, Barlow, et al. · Clinical Cancer Research

Potentiation of temozolomide and topotecan cytotoxicity by PARP inhibitors in a panel of human cancer cell lines.

1999 · CA Delaney, LZ Wang, et al. · UCL Discovery (University College London)

Population pharmacokinetics of CMF in the adjuvant treatment of breast cancer

1999 · MA Batey, JG Wright, et al. · UCL Discovery (University College London)

Works count: 35

Citation count: 73

H-index: 3

I10-index: 2