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Neil T. Thompson

Discovery and Pharmacological Characterization of JNJ-42756493 (Erdafitinib), a Functionally Selective Small-Molecule FGFR Family Inhibitor
2017 · Timothy P.S. Perera, Eleonora Jovcheva, et al. · Molecular Cancer Therapeutics · 346
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Phospholipase D1 localises to secretory granules and lysosomes and is plasma-membrane translocated on cellular stimulation
1998 · Fraser D. Brown, Nicola Thompson, et al. · Current Biology · 206
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Biological characterization of AT7519, a small-molecule inhibitor of cyclin-dependent kinases, in human tumor cell lines
2009 · Matthew S. Squires, Ruth E. Feltell, et al. · Molecular Cancer Therapeutics · 172
Receptor-coupled phospholipase D and its inhibition
1991 · Neil T. Thompson, Robert W. Bonser, et al. · Trends in Pharmacological Sciences · 115
AT13148 Is a Novel, Oral Multi-AGC Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
2012 · Timothy A. Yap, Mike I. Walton, et al. · Clinical Cancer Research · 91
Inhibition of HSP90 by AT13387 Delays the Emergence of Resistance to BRAF Inhibitors and Overcomes Resistance to Dual BRAF and MEK Inhibition in Melanoma Models
2014 · Tomoko Smyth, Kim H.T. Paraiso, et al. · Molecular Cancer Therapeutics · 90
Preclinical Pharmacology, Antitumor Activity, and Development of Pharmacodynamic Markers for the Novel, Potent AKT Inhibitor CCT128930
2010 · Timothy A. Yap, Mike I. Walton, et al. · Molecular Cancer Therapeutics · 82
The heat shock protein 90 inhibitor, AT 13387, displays a long duration of action in vitro and in vivo in non‐small cell lung cancer
2011 · Brent Graham, Jayne Curry, et al. · Cancer Science · 81
ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth
2018 · George A. Ward, Edward J. Lewis, et al. · Molecular Cancer Therapeutics · 72
Activity of the multitargeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL–positive leukemic cells
2010 · Ruriko Tanaka, Matthew S. Squires, et al. · Blood · 69
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Fragment-Based Discovery of a Potent, Orally Bioavailable Inhibitor That Modulates the Phosphorylation and Catalytic Activity of ERK1/2
2018 · Tom D. Heightman, Valerio Berdini, et al. · Journal of Medicinal Chemistry · 63
AT7867 Is a Potent and Oral Inhibitor of AKT and p70 S6 Kinase That Induces Pharmacodynamic Changes and Inhibits Human Tumor Xenograft Growth
2010 · Kyla M. Grimshaw, Lisa-Jane K. Hunter, et al. · Molecular Cancer Therapeutics · 62
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Effects of α2‐adrenoceptor agonists and of related compounds on aggregation of, and on adenylate cyclase activity in, human platelets
1984 · Katherine A. Clare, Michael C. Scrutton, et al. · British Journal of Pharmacology · 61
The HSP90 Inhibitor, AT13387, Is Effective against Imatinib-Sensitive and -Resistant Gastrointestinal Stromal Tumor Models
2012 · Tomoko Smyth, Thomas Van Looy, et al. · Molecular Cancer Therapeutics · 58
Structure-Based Design of Potent and Orally Active Isoindolinone Inhibitors of MDM2-p53 Protein–Protein Interaction
2021 · Gianni Chessari, Ian R. Hardcastle, et al. · Journal of Medicinal Chemistry · 57
AT7519, a Cyclin-Dependent Kinase Inhibitor, Exerts Its Effects by Transcriptional Inhibition in Leukemia Cell Lines and Patient Samples
2010 · Matthew S. Squires, Laurence Cooke, et al. · Molecular Cancer Therapeutics · 56
AT9283, a potent inhibitor of the Aurora kinases and Jak2, has therapeutic potential in myeloproliferative disorders
2010 · Mark A. Dawson, Jayne E. Curry, et al. · British Journal of Haematology · 55
A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H ,2 H ,3 H -pyrrolo[3,2- b ]pyridin-1-yl)-2-[(2 R ,5 R )-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660)
2018 · Christopher N. Johnson, Jong Sook Ahn, et al. · Journal of Medicinal Chemistry · 53
Aurora B kinase inhibition in mitosis: Strategies for optimizing the use of Aurora kinase inhibitors such as AT9283
2009 · Jayne Curry, Hayley Angove, et al. · Cell Cycle · 53
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A novel and sensitive assay for phospholipase D in intact cells
1990 · Roger W. Randall, Robert W. Bonser, et al. · FEBS Letters · 53
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The p85 subunit of phosphoinositide 3-kinase is associated with β-catenin in the cadherin-based adhesion complex
2001 · Richard J. WOODFIELD, Matthew N. HODGKIN, et al. · Biochemical Journal · 51
CD4+CD45RA+ and CD4+CD45RO+ T cells differ in their TCR-associated signaling responses
1999 · Simon R. Hall, Brian M. Heffernan, et al. · European Journal of Immunology · 46
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Synergistic responses in human platelets. Comparison between aggregation, secretion and cytosolic Ca2+ concentration
1986 · Neil T. THOMPSON, Michael C. SCRUTTON, et al. · European Journal of Biochemistry · 41
Potent, Selective Inhibitors of Fibroblast Growth Factor Receptor Define Fibroblast Growth Factor Dependence in Preclinical Cancer Models
2011 · Matthew Squires, George Ward, et al. · Molecular Cancer Therapeutics · 34
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Identification of Small-Molecule Inhibitors of Protein Kinase B (PKB/AKT) in an AlphaScreen™ High-Throughput Screen
2006 · Samantha Burns, Jonathan Travers, et al. · SLAS DISCOVERY · 34
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Works count: 154
Citation count: 2,401
H-index: 27
I10-index: 33
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