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F. M. Sirotnak
Observed names:
F M Sirotnak,
F Sirotnak,
F. M. SIROTNAK,
F. Sirotnak,
F.M. Sirotnak,
Frances M Sirotnak,
Frances M. Sirotnak
show all 7
Institution:
Memorial Sloan Kettering Cancer Center
Observed institutions:
Memorial Sloan Kettering Cancer Center,
Cornell University,
Weill Cornell Medicine,
University of Maryland, College Park
OpenAlex ID:
A5113546804
Relative frequency and kinetic properties of transport-defective phenotypes among methotrexate-resistant L1210 clonal cell lines derived in vivo.
1981
·
F M Sirotnak
, D M Moccio
, et al.
·
PubMed
·
184
Activity of a Novel Anti-folate (PDX, 10-propargyl 10-deazaaminopterin) against Human Lymphoma is Superior to Methotrexate and Correlates with Tumor RFC-1 Gene Expression
2003
·
Eunice S. Wang
, Owen O'Connor
, et al.
·
Leukemia & lymphoma/Leukemia and lymphoma
·
116
New folate analogs of the 10-deaza-aminopterin series: markedly increased antitumor activity of the 10-ethyl analog compared to the parent compound and methotrexate against some human tumor xenografts in nude mice.
1985
·
F A Schmid
, F M Sirotnak
, et al.
·
PubMed
·
69
The epidermal growth factor receptor tyrosine kinase inhibitor ZD1839 selectively potentiates radiation response of human tumors in nude mice, with a marked improvement in therapeutic index.
2003
·
Yuhong She
, Fei Lee
, et al.
·
PubMed
·
68
Kinetic correlates of methotrexate transport and therapeutic responsiveness in murine tumors.
1976
·
F M Sirotnak
, R C Donsbach
·
PubMed
·
64
Microarray analysis of prostate cancer progression to reduced androgen dependence: Studies in unique models contrasts early and late molecular events
2004
·
F.M. Sirotnak
, Yuhong She
, et al.
·
Molecular Carcinogenesis
·
47
Synthesis and antitumor activity of 10-alkyl-10-deazaminopterins. A convenient synthesis of 10-deazaminopterin
1982
·
J. I. DeGraw
, V. H. Brown
, et al.
·
Journal of Medicinal Chemistry
·
47
Increased accumulation of methotrexate by murine tumor cells in vitro in the presence of probenecid which is mediated by a preferential inhibition of efflux.
1981
·
F M Sirotnak
, D M Moccio
, et al.
·
PubMed
·
47
Methotrexate resistance in an in vivo mouse tumor due to a non-active-site dihydrofolate reductase mutation.
1993
·
A P Dicker
, M C Waltham
, et al.
·
Proceedings of the National Academy of Sciences
·
41
Amino Acid Metabolism of Bovine Rumen Bacteria
1953
·
F.M. Sirotnak
, R.N. Doetsch
, et al.
·
Journal of Dairy Science
·
37
PDF
A Population Pharmacokinetic and Pharmacodynamic Evaluation of Pralatrexate in Patients With Relapsed or Refractory Non-Hodgkin's or Hodgkin's Lymphoma
2009
·
D R Mould
, K Sweeney
, et al.
·
Clinical Pharmacology & Therapeutics
·
33
The issues of transport multiplicity and energetics pertaining to methotrexate efflux in L1210 cells addressed by an analysis of cis and trans effects of inhibitors.
1991
·
F M Sirotnak
, D F O'Leary
·
PubMed
·
33
A Phase 1 Study of Pralatrexate in Combination with Paclitaxel or Docetaxel in Patients with Advanced Solid Tumors
2007
·
Christopher G. Azzoli
, Lee M. Krug
, et al.
·
Clinical Cancer Research
·
31
Pharmacokinetic basis for differences in methotrexate sensitivity of normal proliferative tissues in the mouse.
1980
·
F M Sirotnak
, D M Moccio
·
PubMed
·
31
Extent of the requirement for folate transport by L1210 cells for growth and leukemogenesis in vivo.
1985
·
F M Sirotnak
, L J Goutas
, et al.
·
PubMed
·
29
Evidence for the facilitated transport of methotrexate polyglutamates into lysosomes derived from S180 cells. Basic properties and specificity for polyglutamate chain length
1991
·
J.R. Barrueco
, F.M. Sirotnak
·
Journal of Biological Chemistry
·
28
Proposed mechanism of therapeutic selectivity for 9-beta-D-arabinofuranosyl-2-fluoroadenine against murine leukemia based upon lower capacities for transport and phosphorylation in proliferative intestinal epithelium compared to tumor cells.
1987
·
J R Barrueco
, D M Jacobsen
, et al.
·
PubMed
·
27
Biochemical and pharmacokinetic effects of leucovorin after high-dose methotrexate in a murine leukemia model.
1976
·
F M Sirotnak
, R C Donsbach
, et al.
·
PubMed
·
27
Facilitated transport of methotrexate polyglutamates into lysosomes derived from S180 cells. Further characterization and evidence for a simple mobile carrier system with broad specificity for homo- or heteropeptides bearing a C-terminal glutamyl moiety.
1992
·
J.R. Barrueco
, D.F. O'Leary
, et al.
·
Journal of Biological Chemistry
·
23
Pralatrexate (PDX) Produces Durable Complete Remissions in Patients with Chemotherapy Resistant Precursor and Peripheral T-Cell Lymphomas: Results of the MSKCC Phase I/II Experience.
2006
·
Owen A. O’Connor
, P.A. Hamlin
, et al.
·
Blood
·
22
Molecular cloning of the murine cMOAT ATPase
2000
·
Friederike Fritz
, Jing Chen
, et al.
·
Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression
·
21
Phase II Trial of Pralatrexate (10-Propargyl-10-deazaaminopterin, PDX) in Patients with Unresectable Malignant Pleural Mesothelioma
2007
·
Lee M. Krug
, Robert T. Heelan
, et al.
·
Journal of Thoracic Oncology
·
20
Synthesis and antifolate evaluation of the aminopterin analogue with a bicyclo[2.2.2]octane ring in place of the benzene ring
2001
·
Robert C Reynolds
, Cheryl A Johnson
, et al.
·
European Journal of Medicinal Chemistry
·
16
Alteration of folate analogue transport following induced maturation of HL-60 leukemia cells. Early decline in mediated influx, relationship to commitment, and functional dissociation of entry and exit routes.
1986
·
F M Sirotnak
, D M Jacobsen
, et al.
·
Journal of Biological Chemistry
·
16
Experimental therapeutics with a new 10-deazaaminopterin in human mesothelioma: further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases, and combined therapy with platinums.
2001
·
N Z Khokhar
, Y She
, et al.
·
PubMed
·
15
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Works count:
60
Citation count:
1,245
H-index:
21
I10-index:
34
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