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Toshiharu Yoshino

Synthetic studies of huperzine A and its fluorinated analogues. 1. Novel asymmetric syntheses of an enantiomeric pair of huperzine A
1998 · Satoru Kaneko, Toshiharu Yoshino, et al. · Tetrahedron · 87
Synthesis and Conformational Analysis of a Non-Amidine Factor Xa Inhibitor That Incorporates 5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine as S4 Binding Element
2004 · Noriyasu Haginoya, Syozo Kobayashi, et al. · Journal of Medicinal Chemistry · 74
A Total Synthesis of Xestodecalactone A and Proof of Its Absolute Stereochemistry: Interesting Observations on Dienophilic Control with 1,3-Disubstituted Nonequivalent Allenes
2006 · Toshiharu Yoshino, Fay Ng, et al. · Journal of the American Chemical Society · 62
Total synthesis of natural (+)-FR900482. 2. Efficient syntheses of the aromatic and the optically active aliphatic fragments
1996 · Toshiharu Yoshino, Yuriko Nagata, et al. · Tetrahedron Letters · 59
Total synthesis of an enantiomeric pair of FR900482. 1. Synthetic and end-game strategies
1997 · Tadashi Katoh, Etsuko Itoh, et al. · Tetrahedron · 52
A novel enantioselective synthesis of the key intermediate of (−)-huperzine a employing asymmetric palladium-catalyzed bicycloannulation
1997 · Satoru Kaneko, Toshiharu Yoshino, et al. · Tetrahedron Asymmetry · 52
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part II: Exploration of 6–6 fused rings as alternative S1 moieties
2009 · Kenji Yoshikawa, Shozo Kobayashi, et al. · Bioorganic & Medicinal Chemistry · 45
Discovery of N-[(1R,2S,5S)-2-{[(5-chloroindol-2-yl)carbonyl]amino}-5-(dimethylcarbamoyl)cyclohexyl]-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A novel, potent and orally active direct inhibitor of factor Xa
2008 · Tsutomu Nagata, Toshiharu Yoshino, et al. · Bioorganic & Medicinal Chemistry · 43
Total synthesis of an enantiomeric pair of FR900482. 2. Syntheses of the aromatic and the optically active aliphatic segments
1997 · Toshiharu Yoshino, Yuriko Nagata, et al. · Tetrahedron · 43
Total synthesis of natural (+)-FR900482. 1. Synthetic and end-game strategies
1996 · Tadashi Katoh, Etsuko Itoh, et al. · Tetrahedron Letters · 43
Design, synthesis, and biological activity of novel factor Xa inhibitors: Improving metabolic stability by S1 and S4 ligand modification
2005 · Satoshi Komoriya, Shozo Kobayashi, et al. · Bioorganic & Medicinal Chemistry · 42
Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors
2013 · Taiji Goto, Akiko Shiina, et al. · Bioorganic & Medicinal Chemistry Letters · 40
Identification of the 5,5-dioxo-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidine derivatives as highly selective PDE4B inhibitors
2013 · Taiji Goto, Akiko Shiina, et al. · Bioorganic & Medicinal Chemistry Letters · 35
Design, synthesis, and biological activity of non-amidine factor Xa inhibitors containing pyridine N-oxide and 2-carbamoylthiazole units
2004 · Noriyasu Haginoya, Syozo Kobayashi, et al. · Bioorganic & Medicinal Chemistry · 34
Highly efficient synthesis of 13-dehydroprostaglandins by 1,4-addition reaction of alkynyl .omega. side-chain unit onto a cyclopentenone framework
1991 · Toshiharu Yoshino, Sentaro Okamoto, et al. · The Journal of Organic Chemistry · 34
Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors
2007 · Tsutomu Nagata, Toshiharu Yoshino, et al. · Bioorganic & Medicinal Chemistry Letters · 33
A novel biogenetic type synthesis of (+)-hydantocidin
1993 · Miyoko Matsumoto, Masayuki Kirihara, et al. · Tetrahedron Letters · 32
A highly practical synthesis of natural PGE1, Δ2-trans-PGE1 and 2,2,3,3-tetradehydro-PGE1 via two-component coupling process using zinc-copper reagents
1990 · Hiromi Tsujiyama, Naoya Ono, et al. · Tetrahedron Letters · 32
Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: Exploration of 5–6 fused rings as alternative S1 moieties
2009 · Kenji Yoshikawa, Aki Yokomizo, et al. · Bioorganic & Medicinal Chemistry · 31
Design, synthesis, and biological activity of non-basic compounds as factor Xa inhibitors: SAR study of S1 and aryl binding sites
2005 · Satoshi Komoriya, Noriyasu Haginoya, et al. · Bioorganic & Medicinal Chemistry · 29
Total synthesis of an enantiomeric pair of FR900482. 3. Completion of the synthesis by assembling the two segments
1997 · Tadashi Katoh, Yuriko Nagata, et al. · Tetrahedron · 29
Total synthesis of natural (+)-FR900482. 3. Completion of the synthesis
1996 · Tadashi Katoh, Toshiharu Yoshino, et al. · Tetrahedron Letters · 26
An Enantioselective Synthesis of Natural (-)-Huperzine A via Cinchona Alkaloids-promoted Asymmetric Michael Reaction
1997 · Shiro Terashima, Satoru Kaneko, et al. · Heterocycles · 25
Evaluation of the Therapeutic Index of a Novel Phosphodiesterase 4B–Selective Inhibitor Over Phosphodiesterase 4D in Mice
2013 · Osamu Suzuki, Kiyoshi Mizukami, et al. · Journal of Pharmacological Sciences · 24
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Facile Methods for Preparation of Thiazolopyridine and Tetrahydro-thiazolopyridine Derivatives
2004 · Noriyasu Haginoya, Satoshi Komoriya, et al. · Heterocycles · 22
Works count: 46
Citation count: 1,205
H-index: 24
I10-index: 34
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