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Masuo Yamaoka
Observed name:
Yamaoka, Masuo
Institution:
Takeda (Japan)
Observed institution:
Takeda (Japan)
OpenAlex ID:
A5113598620
Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome.
2003
·
Takahito Hara
, Jun-ichi Miyazaki
, et al.
·
PubMed
·
425
Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer
2011
·
Tomohiro Kaku
, Takenori Hitaka
, et al.
·
Bioorganic & Medicinal Chemistry
·
126
Orteronel (TAK-700), a novel non-steroidal 17,20-lyase inhibitor: Effects on steroid synthesis in human and monkey adrenal cells and serum steroid levels in cynomolgus monkeys
2012
·
Masuo Yamaoka
, Takahito Hara
, et al.
·
The Journal of Steroid Biochemistry and Molecular Biology
·
115
Overcoming Persistent Dependency on Androgen Signaling after Progression to Castration-Resistant Prostate Cancer
2010
·
Masuo Yamaoka
, Takahito Hara
, et al.
·
Clinical Cancer Research
·
86
C17,20-lyase inhibitors. Part 2: Design, synthesis and structure–activity relationships of (2-naphthylmethyl)-1H-imidazoles as novel C17,20-lyase inhibitors
2004
·
Nobuyuki Matsunaga
, Tomohiro Kaku
, et al.
·
Bioorganic & Medicinal Chemistry
·
58
Enhanced androgen receptor signaling correlates with the androgen-refractory growth in a newly established MDA PCa 2b-hr human prostate cancer cell subline.
2003
·
Takahito Hara
, Kazuyo Nakamura
, et al.
·
PubMed
·
48
A mutation in β‐tubulin and a sustained dependence on androgen receptor signalling in a newly established docetaxel‐resistant prostate cancer cell line
2009
·
Takahito Hara
, Kazutaka Ushio
, et al.
·
Cell Biology International
·
45
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs) Part III: Discovery of 4-(5-oxopyrrolidine-1-yl)benzonitrile derivative 2f as a clinical candidate
2017
·
Katsuji Aikawa
, Moriteru Asano
, et al.
·
Bioorganic & Medicinal Chemistry
·
41
C17,20-Lyase inhibitors I. Structure-based de novo design and SAR study of C17,20-lyase inhibitors
2004
·
Nobuyuki Matsunaga
, Tomohiro Kaku
, et al.
·
Bioorganic & Medicinal Chemistry
·
41
Possible role of adaptive mutation in resistance to antiandrogen in prostate cancer cells
2005
·
Takahito Hara
, Jin Kouno
, et al.
·
The Prostate
·
35
Prevention of body weight loss and sarcopenia by a novel selective androgen receptor modulator in cancer cachexia models
2017
·
Megumi Morimoto
, Katsuji Aikawa
, et al.
·
Oncology Letters
·
34
PDF
Effect of a novel 17,20-lyase inhibitor, orteronel (TAK-700), on androgen synthesis in male rats
2012
·
Takahito Hara
, Jin Kouno
, et al.
·
The Journal of Steroid Biochemistry and Molecular Biology
·
31
Design, synthesis, and biological evaluation of 4-arylmethyl-1-phenylpyrazole and 4-aryloxy-1-phenylpyrazole derivatives as novel androgen receptor antagonists
2012
·
Satoshi Yamamoto
, Naoki Tomita
, et al.
·
Bioorganic & Medicinal Chemistry
·
29
A selective androgen receptor modulator SARM‐2f activates androgen receptor, increases lean body mass, and suppresses blood lipid levels in cynomolgus monkeys
2020
·
Megumi Morimoto
, Masuo Yamaoka
, et al.
·
Pharmacology Research & Perspectives
·
21
PDF
Selective androgen receptor modulator activity of a steroidal antiandrogen TSAA-291 and its cofactor recruitment profile
2015
·
Yukiko Hikichi
, Masuo Yamaoka
, et al.
·
European Journal of Pharmacology
·
21
Amelioration of sexual behavior and motor activity deficits in a castrated rodent model with a selective androgen receptor modulator SARM-2f
2017
·
Megumi Morimoto
, Yuichiro Amano
, et al.
·
PLoS ONE
·
20
PDF
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part II: Optimization of 4-(pyrrolidin-1-yl)benzonitrile derivatives
2017
·
Moriteru Asano
, Takenori Hitaka
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
20
Synthesis and biological evaluation of novel selective androgen receptor modulators (SARMs). Part I
2015
·
Katsuji Aikawa
, Toshio Miyawaki
, et al.
·
Bioorganic & Medicinal Chemistry
·
20
Design, synthesis, and biological evaluation of 4-phenylpyrrole derivatives as novel androgen receptor antagonists
2011
·
Satoshi Yamamoto
, Nobuyuki Matsunaga
, et al.
·
Bioorganic & Medicinal Chemistry
·
19
17,20-Lyase inhibitors. Part 4: Design, synthesis and structure–activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors
2011
·
Tomohiro Kaku
, Nobuyuki Matsunaga
, et al.
·
Bioorganic & Medicinal Chemistry
·
14
Design, synthesis, and biological evaluation of 3-aryl-3-hydroxy-1-phenylpyrrolidine derivatives as novel androgen receptor antagonists
2012
·
Satoshi Yamamoto
, Hiromi Kobayashi
, et al.
·
Bioorganic & Medicinal Chemistry
·
9
17,20-Lyase inhibitors. Part 3: Design, synthesis, and structure–activity relationships of biphenylylmethylimidazole derivatives as novel 17,20-lyase inhibitors
2011
·
Tomohiro Kaku
, Saori Tsujimoto
, et al.
·
Bioorganic & Medicinal Chemistry
·
7
Acceleration of wound healing by recombinant human basic fibroblast growth factor in a rat sponge-implantation model.
1991
·
Masuo Yamaoka
, Tsuneo Masaki
, et al.
·
Ensho
·
7
PDF
Effect of an investigational CYP17A1 inhibitor, orteronel (TAK-700), on estrogen- and corticoid-synthesis pathways in hypophysectomized female rats and on the serum estradiol levels in female cynomolgus monkeys
2013
·
Masuo Yamaoka
, Takahito Hara
, et al.
·
The Journal of Steroid Biochemistry and Molecular Biology
·
6
CCDC 1526940: Experimental Crystal Structure Determination
2017
·
Aikawa, Katsuji
, Asano, Moriteru
, et al.
·
The Cambridge Structural Database
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Works count:
30
Citation count:
1,278
H-index:
19
I10-index:
20
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