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David L. Pompliano

Drugs for bad bugs: confronting the challenges of antibacterial discovery
2006 · David J. Payne, Michael N. Gwynn, et al. · Nature Reviews Drug Discovery · 2,493
Drug–target residence time and its implications for lead optimization
2006 · Robert A. Copeland, David L. Pompliano, et al. · Nature Reviews Drug Discovery · 1,461
Selective Inhibition of ras -Dependent Transformation by a Farnesyltransferase Inhibitor
1993 · Nancy E. Kohl, Scott D. Mosser, et al. · Science · 573
Stabilization of a reaction intermediate as a catalytic device: definition of the functional role of the flexible loop in triosephosphate isomerase
1990 · David L. Pompliano, Anusch Peyman, et al. · Biochemistry · 272
Steady-state kinetic mechanism of ras farnesyl:protein transferase
1992 · David L. Pompliano, Elaine Rands, et al. · Biochemistry · 246
Antibiotic sensitization using biphenyl tetrazoles as potent inhibitors of Bacteroides fragilis metallo-β-lactamase
1998 · Jeffrey H. Toney, Paula M.D. Fitzgerald, et al. · Chemistry & Biology · 242
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A Murine Model of falciparum-Malaria by In Vivo Selection of Competent Strains in Non-Myelodepleted Mice Engrafted with Human Erythrocytes
2008 · Iñigo Angulo-Barturen, María Belén Jiménez-Díaz, et al. · PLoS ONE · 163
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Intramolecular fluorescence enhancement: a continuous assay of Ras farnesyl:protein transferase
1992 · David L. Pompliano, Robert P. Gomez, et al. · Journal of the American Chemical Society · 139
Conditionally Lethal Escherichia coli Murein Mutants Contain Point Defects That Map to Regions Conserved among Murein and Folyl Poly-γ-glutamate Ligases: Identification of a Ligase Superfamily
1997 · Suzanne S. Eveland, David L. Pompliano, et al. · Biochemistry · 114
An array of target-specific screening strains for antibacterial discovery
2002 · Joseph A. DeVito, Jonathan A. Mills, et al. · Nature Biotechnology · 112
Pseudopeptide Inhibitors of Ras Farnesyl-Protein Transferase
1994 · Samuel L. Graham, S. Jane deSolms, et al. · Journal of Medicinal Chemistry · 107
Anti-infective research and development—problems, challenges, and solutions
2006 · John S Bradley, Robert Guidos, et al. · The Lancet Infectious Diseases · 97
Isoprenoid diphosphate utilization by recombinant human farnesyl:protein transferase: Interactive binding between substrates and a preferred kinetic pathway
1993 · David L. Pompliano, Michael D. Schaber, et al. · Biochemistry · 96
Structural homology among mammalian and Saccharomyces cerevisiae isoprenyl-protein transferases.
1991 · N.E. Kohl, R.E. Diehl, et al. · Journal of Biological Chemistry · 90
Kinetic Mechanism of the Escherichia coli UDPMurNAc-Tripeptide d -Alanyl- d -alanine-Adding Enzyme: Use of a Glutathione S-Transferase Fusion
1996 · Matt S. Anderson, Suzanne S. Eveland, et al. · Biochemistry · 83
Phosphonate biosynthesis: molecular cloning of the gene for phosphoenolpyruvate mutase from Tetrahymena pyriformis and overexpression of the gene product in Escherichia coli
1992 · H. Martin Seidel, David L. Pompliano, et al. · Biochemistry · 60
Synthesis and SAR of thioester and thiol inhibitors of IMP-1 Metallo-β-Lactamase
1999 · Mark L. Greenlee, Joanne B. Laub, et al. · Bioorganic & Medicinal Chemistry Letters · 58
Oxazolidinones Mechanism of Action: Inhibition of the First Peptide Bond Formation
2001 · Utpal Patel, Yong P. Yan, et al. · Journal of Biological Chemistry · 57
A Phosphinate Inhibitor of the meso-Diaminopimelic Acid-Adding Enzyme (MurE) of Peptidoglycan Biosynthesis
1998 · Binqi Zeng, Kenny K. Wong, et al. · The Journal of Organic Chemistry · 52
2-Substituted Piperazines as Constrained Amino Acids. Application to the Synthesis of Potent, Non Carboxylic Acid Inhibitors of Farnesyltransferase
1996 · Theresa M. Williams, Terrence M. Ciccarone, et al. · Journal of Medicinal Chemistry · 51
Inhibition of IMP-1 metallo-β-lactamase and sensitization of IMP-1-producing bacteria by thioester derivatives
1999 · Gail G. Hammond, Joann L. Huber, et al. · FEMS Microbiology Letters · 50
Development of a Whole-Cell Assay for Peptidoglycan Biosynthesis Inhibitors
2002 · Maria D. F. S. Barbosa, Gaoyun Yang, et al. · Antimicrobial Agents and Chemotherapy · 49
Preparative Enzymatic Synthesis and Characterization of the Cytoplasmic Intermediates of Murein Biosynthesis
1999 · Sreelatha G. Reddy, Sherman T. Waddell, et al. · Journal of the American Chemical Society · 46
Catalytic Properties of Mutant 23 S Ribosomes Resistant to Oxazolidinones
2003 · Ekaterina V. Bobkova, Yong Ping Yan, et al. · Journal of Biological Chemistry · 40
Diverse Fragment Clustering and Water Exclusion Identify Protein Hot Spots
2011 · John L. Kulp, John L. Kulp, et al. · Journal of the American Chemical Society · 38
Works count: 49
Citation count: 7,197
H-index: 29
I10-index: 43
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