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Marco M. Kessler

Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit
2010 · Robert W. Busby, Alexander P. Bryant, et al. · European Journal of Pharmacology · 236
Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3′-end formation in yeast
1997 · Marco M. Kessler, Michael F. Henry, et al. · Genes & Development · 231
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Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract
2010 · Alexander P. Bryant, Robert W. Busby, et al. · Life Sciences · 209
Pharmacologic Properties, Metabolism, and Disposition of Linaclotide, a Novel Therapeutic Peptide Approved for the Treatment of Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation
2012 · Robert W. Busby, Marco M. Kessler, et al. · Journal of Pharmacology and Experimental Therapeutics · 140
Pta1, a Component of Yeast CF II, Is Required for Both Cleavage and Poly(A) Addition of mRNA Precursor
1999 · Jing Zhao, Marco Kessler, et al. · Molecular and Cellular Biology · 89
Purification of the Saccharomyces cerevisiae Cleavage/Polyadenylation Factor I
1996 · Marco M. Kessler, Jing Zhao, et al. · Journal of Biological Chemistry · 88
Identification of potential cell‐surface proteins in Candida albicans and investigation of the role of a putative cell‐surface glycosidase in adhesion and virulence
2004 · Christine Alberti‐Segui, Arturo J. Morales, et al. · Yeast · 74
Gastrointestinal pain: Unraveling a novel endogenous pathway through uroguanylin/guanylate cyclase-C/cGMP activation
2013 · Inmaculada Silos-Santiago, Gerhard Hannig, et al. · Pain · 68
Cleavage Factor II of Saccharomyces cerevisiaeContains Homologues to Subunits of the Mammalian Cleavage/ Polyadenylation Specificity Factor and Exhibits Sequence-specific, ATP-dependent Interaction with Precursor RNA
1997 · Jing Zhao, Marco M. Kessler, et al. · Journal of Biological Chemistry · 60
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Systematic Discovery of New Genes in the Saccharomyces cerevisiae Genome
2003 · Marco M. Kessler, Qiandong Zeng, et al. · Genome Research · 58
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Linaclotide activates guanylate cyclase-C/cGMP/protein kinase-II-dependent trafficking of CFTR in the intestine
2017 · Md. Kaimul Ahsan, Boris Tchernychev, et al. · Physiological Reports · 49
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Structure-Function Relationships in the Saccharomyces cerevisiae Poly(A) Polymerase
1995 · Alexander M. Zhelkovsky, Marco M. Kessler, et al. · Journal of Biological Chemistry · 49
Requirement of A-A-U-A-A-A and adjacent downstream sequences for SV40 early potyadenylation
1986 · Marco M. Kessler, Richard C. Beckendorf, et al. · Nucleic Acids Research · 30
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Monoclonal antibodies to yeast poly(A) polymerase (PAP) provide evidence for association of PAP with cleavage factor I
1995 · Marco M. Kessler, Alexander M. Zhelkovsky, et al. · Biochemistry · 28
The Soluble Guanylate Cyclase Stimulator IWP-953 Increases Conventional Outflow Facility in Mouse Eyes
2016 · Pei Ge, Iris D. Navarro, et al. · Investigative Ophthalmology & Visual Science · 26
MRP4 Modulation of the Guanylate Cyclase-C/cGMP Pathway: Effects on Linaclotide-Induced Electrolyte Secretion and cGMP Efflux
2015 · Boris Tchernychev, Pei Ge, et al. · Journal of Pharmacology and Experimental Therapeutics · 26
Guanylate cyclase 2C agonism corrects CFTR mutants
2017 · Kavisha Arora, Yunjie Huang, et al. · JCI Insight · 21
The use of direct cDNA selection to rapidly and effectively identify genes in the fungus Aspergillus fumigatus
2002 · Marco M Kessler, Debra Aker Willins, et al. · Fungal Genetics and Biology · 17
The Natriuretic Peptide Uroguanylin Elicits Physiologic Actions Through 2 Distinct Topoisomers
2009 · Nicholas G. Moss, Dorothy A. Riguera, et al. · Hypertension · 16
Pilot study evaluating salivary bile acids as a diagnostic biomarker of laryngopharyngeal reflux
2024 · Amanda J Krause, Madeline Greytak, et al. · Diseases of the Esophagus · 15
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Genomics Strategies for Antifungal Drug Discovery - From Gene Discovery to Compound Screening
2002 · Debra Willins, Marco Kessler, et al. · Current Pharmaceutical Design · 13
Polyadenylation at a cryptic site in the pBR322 portion of pSV2-neo: prevention of its utilization by the SV40 late poly(A) signal
1987 · Marco M. Kessler, Mark A. Westhafer, et al. · Nucleic Acids Research · 11
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Polyadenylylation of sea urchin histone RNA sequences in transfected COS cells.
1985 · J L Nordstrom, S L Hall, et al. · Proceedings of the National Academy of Sciences · 10
Tu1211 IW-9179, a Phosphopeptide Designed to Target the Upper Gastrointestinal Tract, Is More Potent at Acidic pH and Is Rapidly Metabolized In Vitro in Rodent Intestinal Fluid
2015 · Marco Kessler, Robert Solinga, et al. · Gastroenterology · 2
A Comparison of the Physical and Pharmacological Properties of Plecanatide (SP-304) and the Human Hormone Uroguanylin
2011 · Robert Solinga, Marco Kessler, et al. · The American Journal of Gastroenterology · 2
Works count: 38
Citation count: 1,570
H-index: 17
I10-index: 23
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