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Doug W. Hobbs

Structure-Based Drug Design and Optimization of Mannoside Bacterial FimH Antagonists
2010 · Zhenfu Han, Jerome S. Pinkner, et al. · Journal of Medicinal Chemistry · 239
Development of BACE1 Inhibitors for Alzheimers Disease
2006 · Tao Guo, Doug Hobbs · Current Medicinal Chemistry · 101
Orally active, nonpeptide oxytocin antagonists
1992 · Ben E. Evans, James L. Leighton, et al. · Journal of Medicinal Chemistry · 79
Development of Orally Active Oxytocin Antagonists: Studies on 1-(1-{4-[1-(2-Methyl-1-oxidopyridin-3-ylmethyl)piperidin-4-yloxy]-2- methoxybenzoyl}piperidin-4-yl)-1,4-dihydrobenz[d][1,3]oxazin-2-one (L-372,662) and Related Pyridines
1998 · Ian M. Bell, Jill M. Erb, et al. · Journal of Medicinal Chemistry · 60
Synthesis and anti-herpes virus activity of acyclic 2'-deoxyguanosine analogs related to 9-[(1,3-dihydroxy-2-propoxy)methyl]guanine
1986 · John C. Martin, Danny P. C. McGee, et al. · Journal of Medicinal Chemistry · 58
Deriving Knowledge through Data Mining High-Throughput Screening Data
2004 · David J. Diller, Doug W. Hobbs · Journal of Medicinal Chemistry · 48
Privileged Structure-Based Combinatorial Libraries Targeting G Protein-Coupled Receptors
2003 · Tao Guo, Doug W. Hobbs · Assay and Drug Development Technologies · 45
Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as γ-secretase inhibitors
2007 · Tao Guo, Huizhong Gu, et al. · Bioorganic & Medicinal Chemistry Letters · 37
Synthesis of diphenyl thioether derivatives of peptides and aminoacids
1987 · Doug W. Hobbs, W.Clark Still · Tetrahedron Letters · 35
Novel CXCR3 antagonists with a piperazinyl-piperidine core
2009 · Brian F. McGuinness, Carolyn DiIanni Carroll, et al. · Bioorganic & Medicinal Chemistry Letters · 25
II. SAR studies of pyridyl–piperazinyl-piperidine derivatives as CXCR3 chemokine antagonists
2010 · Yuefei Shao, Gopinadhan N. Anilkumar, et al. · Bioorganic & Medicinal Chemistry Letters · 22
Understanding hERG inhibition with QSAR models based on a one-dimensional molecular representation
2007 · David J. Diller, Doug W. Hobbs · Journal of Computer-Aided Molecular Design · 19
IV. Discovery of CXCR3 antagonists substituted with heterocycles as amide surrogates: Improved PK, hERG and metabolic profiles
2014 · Anilkumar G. Nair, Michael K.C. Wong, et al. · Bioorganic & Medicinal Chemistry Letters · 18
Discovery and SAR of 4-amino-2-biarylbutylurea MCH 1 receptor antagonists through solid-phase parallel synthesis
2005 · Tao Guo, Rachael C. Hunter, et al. · Bioorganic & Medicinal Chemistry Letters · 18
III. Identification of novel CXCR3 chemokine receptor antagonists with a pyrazinyl–piperazinyl–piperidine scaffold
2011 · Seong Heon Kim, Gopinadhan N. Anilkumar, et al. · Bioorganic & Medicinal Chemistry Letters · 17
Biological Examination of Melanin Concentrating Hormone Receptor 1: Multi-tasking from the Hypothalamus
2006 · Laura L Rokosz, Douglas W Hobbs · Drug News & Perspectives · 16
Discovery and SAR of biaryl piperidine MCH1 receptor antagonists through solid-phase encoded combinatorial synthesis
2005 · Tao Guo, Yuefei Shao, et al. · Bioorganic & Medicinal Chemistry Letters · 15
Computational ADME/Tox Modeling: Aiding Understanding and Enhancing Decision Making in Drug Design
2005 · Robert Delisle, Jeffery Lowrie, et al. · Current Computer - Aided Drug Design · 14
Synthesis of a Thioether Analog of the Macrocyclic Tripeptide K-13
1989 · Doug W. Hobbs, W. Clark Still · Tetrahedron Letters · 13
Non-peptide oxytocin antagonists: identification and synthesis of a potent camphor aminosuccinimide
1995 · Doug W. Hobbs, Norman P. Gould, et al. · Bioorganic & Medicinal Chemistry Letters · 7
Library Design Concepts and Implementation Strategies*
2001 · Doug W. Hobbs, Tao Guo · Journal of Receptors and Signal Transduction · 6
Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists
2006 · Tao Guo, Huizhong Gu, et al. · Bioorganic & Medicinal Chemistry Letters · 5
Preparation of Encoded Combinatorial Libraries for Drug Discovery
2003 · Tao Guo, Doug W. Hobbs · Humana Press eBooks · 4
Works count: 23
Citation count: 901
H-index: 16
I10-index: 19
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