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Alfred A. Rabow

AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1 -Mutant Breast Tumors in Preclinical Models
2016 · Hazel M. Weir, Robert H. Bradbury, et al. · Cancer Research · 177
Optimization of a Novel Binding Motif to ( E )-3-(3,5-Difluoro-4-((1 R ,3 R )-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1 H -pyrido[3,4- b ]indol-1-yl)phenyl)acrylic Acid (AZD9496), a Potent and Orally Bioavailable Selective Estrogen Receptor Downregulator and Antagonist
2015 · Chris De Savi, Robert H. Bradbury, et al. · Journal of Medicinal Chemistry · 170
AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies
2016 · Garrett W. Rhyasen, Maureen M. Hattersley, et al. · Molecular Cancer Therapeutics · 161
Mining the National Cancer Institute's Tumor-Screening Database: Identification of Compounds with Similar Cellular Activities
2002 · Alfred A. Rabow, Robert H. Shoemaker, et al. · Journal of Medicinal Chemistry · 140
Potent and selective bivalent inhibitors of BET bromodomains
2016 · Michael J Waring, Huawei Chen, et al. · Nature Chemical Biology · 130
Application of High-Throughput, Molecular-Targeted Screening to Anticancer Drug Discovery
2002 · Robert Shoemaker, Dominic Scudiero, et al. · Current Topics in Medicinal Chemistry · 90
Optimization of a Series of Bivalent Triazolopyridazine Based Bromodomain and Extraterminal Inhibitors: The Discovery of (3R)-4-[2-[4-[1-(3-Methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-1,3-dimethyl-piperazin-2-one (AZD5153)
2016 · Robert H. Bradbury, Rowena Callis, et al. · Journal of Medicinal Chemistry · 87
Molecular classification of cancer: unsupervised self-organizing map analysis of gene expression microarray data.
2003 · David G Covell, Anders Wallqvist, et al. · PubMed · 86
AZD3514: A Small Molecule That Modulates Androgen Receptor Signaling and Function In Vitro and In Vivo
2013 · Sarah A. Loddick, Sarah J. Ross, et al. · Molecular Cancer Therapeutics · 79
Improved genetic algorithm for the protein folding problem by use of a Cartesian combination operator
1996 · Alfred A. Rabow, Harold A. Scheraga · Protein Science · 71
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Discovery of AZD3514, a small-molecule androgen receptor downregulator for treatment of advanced prostate cancer
2013 · Robert H. Bradbury, David G. Acton, et al. · Bioorganic & Medicinal Chemistry Letters · 56
Establishing connections between microarray expression data and chemotherapeutic cancer pharmacology.
2002 · Anders Wallqvist, Alfred A Rabow, et al. · PubMed · 51
Small-molecule androgen receptor downregulators as an approach to treatment of advanced prostate cancer
2011 · Robert H. Bradbury, Neil J. Hales, et al. · Bioorganic & Medicinal Chemistry Letters · 47
Tetrahydroisoquinoline Phenols: Selective Estrogen Receptor Downregulator Antagonists with Oral Bioavailability in Rat
2015 · James S. Scott, Andrew Bailey, et al. · ACS Medicinal Chemistry Letters · 43
Discovery of a Potent and Selective ATAD2 Bromodomain Inhibitor with Antiproliferative Activity in Breast Cancer Models
2022 · Jon J. Winter-Holt, Catherine Bardelle, et al. · Journal of Medicinal Chemistry · 40
Linking tumor cell cytotoxicity to mechanism of drug action: An integrated analysis of gene expression, small‐molecule screening and structural databases
2005 · David G. Covell, Anders Wallqvist, et al. · Proteins Structure Function and Bioinformatics · 40
Linking the growth inhibition response from the National Cancer Institute's anticancer screen to gene expression levels and other molecular target data
2003 · Anders Wallqvist, Alfred A. Rabow, et al. · Bioinformatics · 32
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A Screening Assay Cascade to Identify and Characterize Novel Selective Estrogen Receptor Downregulators (SERDs)
2015 · Rowena Callis, Alfred Rabow, et al. · SLAS DISCOVERY · 29
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Enantiomeric pairs reveal that key medicinal chemistry parameters vary more than simple physical property based models can explain
2012 · Andrew G. Leach, Elizabeth A. Pilling, et al. · MedChemComm · 25
Data mining of NCI's anticancer screening database reveals mitochondrial complex I inhibitors cytotoxic to leukemia cell lines
2006 · Constance J. Glover, Alfred A. Rabow, et al. · Biochemical Pharmacology · 15
Mining the NCI screening database: explorations of agents involved in cell cycle regulation.
2003 · Anders Wallqvist, Anne Monks, et al. · PubMed · 6
Abstract 3650: Discovery of the clinical candidate AZD9496: a potent and orally bioavailable selective estrogen receptor downregulator and antagonist
2015 · Chris De Savi, Robert H. Bradbury, et al. · Cancer Research · 4
Abstract DDT01-03: Discovery and pre-clinical pharmacology of AZD9496: An oral, selective estrogen receptor down-regulator (SERD)
2015 · Hazel Weir, Mandy Lawson, et al. · Cancer Research · 2
Data from AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies
2023 · Garrett W. Rhyasen, Maureen M. Hattersley, et al.
Data from AZD5153: A Novel Bivalent BET Bromodomain Inhibitor Highly Active against Hematologic Malignancies
2023 · Garrett W. Rhyasen, Maureen M. Hattersley, et al.
Works count: 43
Citation count: 1,581
H-index: 19
I10-index: 20
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