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Thelma S. Angeles
Observed names:
Angeles, T.S.,
Angeles, Thelma S.,
T Angeles,
T. S. ANGELES,
T.S. Angeles,
Thelma Angeles,
Thelma S Angeles
show all 7
Institution:
Teva Pharmaceuticals (United States)
Observed institutions:
University of Akron,
Albert Einstein College of Medicine,
Emory University,
Sanofi (France),
Institute of General & Endovascular Neurosurgery,
Teva Pharmaceuticals (United States),
Winship Cancer Institute,
University of Turin
show all 8
OpenAlex ID:
A5113679910
Motoneuron Apoptosis Is Blocked by CEP-1347 (KT 7515), a Novel Inhibitor of the JNK Signaling Pathway
1998
·
Anna C. Maroney
, Marcie A. Glicksman
, et al.
·
Journal of Neuroscience
·
293
PDF
Lestaurtinib (CEP701) is a JAK2 inhibitor that suppresses JAK2/STAT5 signaling and the proliferation of primary erythroid cells from patients with myeloproliferative disorders
2007
·
Elizabeth O. Hexner
, Cynthia Serdikoff
, et al.
·
Blood
·
252
CEP-1347 (KT7515), a Semisynthetic Inhibitor of the Mixed Lineage Kinase Family
2001
·
Anna C. Maroney
, James P. Finn
, et al.
·
Journal of Biological Chemistry
·
204
PDF
Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555).
1999
·
D J George
, C A Dionne
, et al.
·
PubMed
·
125
CEP-7055: a novel, orally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical models.
2003
·
Bruce Ruggeri
, Jasbir Singh
, et al.
·
PubMed
·
124
Neurotrophic 3,9-Bis[(alkylthio)methyl]- and -Bis(alkoxymethyl)-K-252a Derivatives
1997
·
Masami Kaneko
, Yutaka Saito
, et al.
·
Journal of Medicinal Chemistry
·
119
Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors
2016
·
Thelma S. Angeles
, Robert L. Hudkins
·
Expert Opinion on Drug Discovery
·
114
Structure-guided identification of novel VEGFR-2 kinase inhibitors via solution phase parallel synthesis
2006
·
Rabindranath Tripathy
, Alyssa Reiboldt
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
106
Anaplastic lymphoma kinase activity is essential for the proliferation and survival of anaplastic large-cell lymphoma cells
2005
·
Weihua Wan
, Mark S. Albom
, et al.
·
Blood
·
106
Mixed lineage kinase activity of indolocarbazole analogues
2002
·
Chikara Murakata
, Masami Kaneko
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
93
Discovery of Clinical Candidate CEP-37440, a Selective Inhibitor of Focal Adhesion Kinase (FAK) and Anaplastic Lymphoma Kinase (ALK)
2016
·
Gregory R. Ott
, Mangeng Cheng
, et al.
·
Journal of Medicinal Chemistry
·
92
1,2,3-Thiadiazole substituted pyrazolones as potent KDR/VEGFR-2 kinase inhibitors
2006
·
Rabindranath Tripathy
, Arup Ghose
, et al.
·
Bioorganic & Medicinal Chemistry Letters
·
92
A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis
2011
·
Kristine L Stump
, Lily D Lu
, et al.
·
Arthritis Research & Therapy
·
78
PDF
CEP-751 inhibits trk receptor tyrosine kinase activityin vitro and exhibits anti-tumor activity
1997
·
Anna Marie Camoratto
, Jitesh P. Jani
, et al.
·
International Journal of Cancer
·
76
PDF
A New Class of Potent Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors: Structure−Activity Relationships for a Series of 9-Alkoxymethyl-12-(3-hydroxypropyl)indeno[2,1-a]pyrrolo[3,4-c]carbazole-5-ones and the Identification of CEP-5214 and Its Dimethylglycine Ester Prodrug Clinical Candidate CEP-7055
2003
·
Diane E. Gingrich
, Dandu R. Reddy
, et al.
·
Journal of Medicinal Chemistry
·
75
Depletion of Autoreactive Plasma Cells and Treatment of Lupus Nephritis in Mice Using CEP-33779, a Novel, Orally Active, Selective Inhibitor of JAK2
2011
·
Lily D Lu
, Kristine L Stump
, et al.
·
The Journal of Immunology
·
74
PDF
CEP-28122, a Highly Potent and Selective Orally Active Inhibitor of Anaplastic Lymphoma Kinase with Antitumor Activity in Experimental Models of Human Cancers
2011
·
Mangeng Cheng
, Matthew R. Quail
, et al.
·
Molecular Cancer Therapeutics
·
73
Antibody-Catalyzed Hydrolysis of an Unsubstituted Amide
1994
·
Mark T. Martin
, Thelma S. Angeles
, et al.
·
Journal of the American Chemical Society
·
69
A Selective, Orally Bioavailable 1,2,4-Triazolo[1,5- a ]pyridine-Based Inhibitor of Janus Kinase 2 for Use in Anticancer Therapy: Discovery of CEP-33779
2012
·
Benjamin J. Dugan
, Diane E. Gingrich
, et al.
·
Journal of Medicinal Chemistry
·
65
Use of nitrogen-15 kinetic isotope effects to elucidate details of the chemical mechanism of human immunodeficiency virus 1 protease
1993
·
Evelyn J. Rodriguez
, Thelma S. Angeles
, et al.
·
Biochemistry
·
54
Discovery of a Potent Inhibitor of Anaplastic Lymphoma Kinase with in Vivo Antitumor Activity
2010
·
Gregory R. Ott
, Rabindranath Tripathy
, et al.
·
ACS Medicinal Chemistry Letters
·
50
Mixed-Lineage Kinase 1 and Mixed-Lineage Kinase 3 Subtype-Selective Dihydronaphthyl[3,4-a]pyrrolo[3,4-c]carbazole-5-ones: Optimization, Mixed-Lineage Kinase 1 Crystallography, and Oral in Vivo Activity in 1-Methyl-4-phenyltetrahydropyridine Models
2008
·
Robert L. Hudkins
, James L. Diebold
, et al.
·
Journal of Medicinal Chemistry
·
44
Synthesis and Biological Profile of the pan-Vascular Endothelial Growth Factor Receptor/Tyrosine Kinase with Immunoglobulin and Epidermal Growth Factor-Like Homology Domains 2 (VEGF-R/TIE-2) Inhibitor 11-(2-Methylpropyl)-12,13-dihydro-2-methyl-8-(pyrimidin-2-ylamino)-4H-indazolo[5,4-a]pyrrolo[3,4-c]carbazol-4-one (CEP-11981): A Novel Oncology Therapeutic Agent
2011
·
Robert L. Hudkins
, Nadine C. Becknell
, et al.
·
Journal of Medicinal Chemistry
·
42
2,7-Disubstituted-pyrrolo[2,1-f][1,2,4]triazines: New Variant of an Old Template and Application to the Discovery of Anaplastic Lymphoma Kinase (ALK) Inhibitors with in Vivo Antitumor Activity
2011
·
Gregory R. Ott
, Gregory J. Wells
, et al.
·
Journal of Medicinal Chemistry
·
42
Enzyme-Linked Immunosorbent Assay for trkA Tyrosine Kinase Activity
1996
·
Thelma S. Angeles
, Catherine Steffler
, et al.
·
Analytical Biochemistry
·
42
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Works count:
101
Citation count:
3,344
H-index:
32
I10-index:
57
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