Author

Jürgen Groet

Observed names: GROET J, Groet, J, J Groet, Jurgen Groet, Jürgen Groet, Jűrgen Groet, J�rgen Groet

Institutions: Queen Mary University of London, Blizard Institute

Observed institutions: Leiden University, University of London, Centre National de la Recherche Scientifique, St Bartholomew's Hospital, University of Antwerp, Max Planck Society, Queen Mary University of London, King's College London, Royal London Hospital, Vlaams Instituut voor Biotechnologie, Blizard Institute, UCL School of Pharmacy, University College London, Wellcome Trust

OpenAlex ID: A5113685539

The importance of understanding individual differences in Down syndrome

2016 · Annette Karmiloff-Smith, Tamara Al-Janabi, et al. · F1000Research · 210

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Acquired mutations in GATA1 in neonates with Down's syndrome with transient myeloid disorder

2003 · Jürgen Groet, Suzanne McElwaine, et al. · The Lancet · 166

DYRK1A-Dosage Imbalance Perturbs NRSF/REST Levels, Deregulating Pluripotency and Embryonic Stem Cell Fate in Down Syndrome

2008 · Claudia Canzonetta, Claire Mulligan, et al. · The American Journal of Human Genetics · 158

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Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene dose-sensitive AD suppressor in human brain

2020 · Ivan Alić, Pollyanna A. Goh, et al. · Molecular Psychiatry · 123

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Tumorigenesis in Down's syndrome: big lessons from a small chromosome

2012 · Dean Nižetić, Jürgen Groet · Nature reviews. Cancer · 99

Brief Report: Isogenic Induced Pluripotent Stem Cell Lines From an Adult With Mosaic Down Syndrome Model Accelerated Neuronal Ageing and Neurodegeneration

2015 · Aoife Murray, Audrey Letourneau, et al. · Stem Cells · 78

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Exome sequencing identifies putative drivers of progression of transient myeloproliferative disorder to AMKL in infants with Down syndrome

2013 · Sergey I. Nikolaev, Federico Santoni, et al. · Blood · 78

Microarray transcript profiling distinguishes the transient from the acute type of megakaryoblastic leukaemia (M7) in Down's syndrome, revealing PRAME as a specific discriminating marker

2004 · Suzanne McElwaine, Claire Mulligan, et al. · British Journal of Haematology · 69

Frequent cases of RAS-mutated Down syndrome acute lymphoblastic leukaemia lack JAK2 mutations

2014 · Sergey I. Nikolaev, Marco Garieri, et al. · Nature Communications · 65

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Neurofilament light as a blood biomarker for neurodegeneration in Down syndrome

2018 · Andre Strydom, Amanda Heslegrave, et al. · Alzheimer s Research & Therapy · 60

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Loss‐of‐function JAK3 mutations in TMD and AMKL of Down syndrome

2007 · Serena De Vita, Claire Mulligan, et al. · British Journal of Haematology · 55

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Intracerebral haemorrhage in Down syndrome: protected or predisposed?

2016 · Lewis Buss, Elizabeth Fisher, et al. · F1000Research · 48

Trisomic dose of several chromosome 21 genes perturbs haematopoietic stem and progenitor cell differentiation in Down's syndrome

2010 · S De Vita, C Canzonetta, et al. · Oncogene · 48

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Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels

2023 · Aoife Murray, Gillian Gough, et al. · EBioMedicine · 35

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Rieger syndrome locus: a new reciprocal translocation t(4;12)(q25;q15) and a deletion del(4)(q25q27) both break between markers D4S2945 and D4S193.

1997 · R H Flomen, P A Gorman, et al. · Journal of Medical Genetics · 29

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Two Sequence-Ready Contigs Spanning the Two Copies of a 200-kb Duplication on Human 21q: Partial Sequence and Polymorphisms

1998 · M.-C Potier, A Dutriaux, et al. · Genomics · 22

Bacterial Contig Map of the 21q11 Region Associated with Alzheimer’s Disease and Abnormal Myelopoiesis in Down Syndrome

1998 · Jürgen Groet, Jane H. Ives, et al. · Genome Research · 22

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Modeling Down syndrome in cells: From stem cells to organoids

2019 · Gillian Gough, Niamh L. O'Brien, et al. · Progress in brain research · 20

Transchromosomic cell model of Down syndrome shows aberrant migration, adhesion and proteome response to extracellular matrix

2009 · Frédéric Delom, Emma Burt, et al. · Proteome Science · 19

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Quantitative Proteomics Characterization of a Mouse Embryonic Stem Cell Model of Down Syndrome

2008 · Yuqin Wang, Claire Mulligan, et al. · Molecular & Cellular Proteomics · 19

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RAS-protein activation but not mutation status is an outcome predictor and unifying therapeutic target for high-risk acute lymphoblastic leukemia

2020 · David Koschut, Debleena Ray, et al. · Oncogene · 15

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Non-recombinant background in gene targeting: illegitimate recombination between a hpt gene and a defective 5′ deleted nptII gene can restore a Kmr phenotype in tobacco

1994 · Marcel J. A. de Groot, Remko Offringa, et al. · Plant Molecular Biology · 15

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Independent clones at separable stages of differentiation, bearing different GATA1 mutations, in the same TMD patient with Down syndrome

2005 · Jürgen Groet, Claire Mulligan, et al. · Blood · 13

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Amplified segment in the ‘Down Syndrome critical region’ on HSA21 shared between Down syndrome and euploid AML‐M0 excludes RUNX1, ERG and ETS2

2012 · Claudia Canzonetta, Alexander Hoischen, et al. · British Journal of Haematology · 11

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Narrowing of the region of allelic loss in 21q11-21 in squamous non-small cell lung carcinoma and cloning of a novel ubiquitin-specific protease gene from the deleted segment

2000 · J�rgen Groet, Jane H. Ives, et al. · Genes Chromosomes and Cancer · 10

Works count: 39

Citation count: 1,500

H-index: 19

I10-index: 25