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Christopher A. Lepre
Observed names:
C. A. LEPRE,
C. A. Lepre,
C.A Lepre,
C.A. Lepre,
Christopher A Lepre,
Christopher Lepre,
ChristopherA. Lepre
show all 7
Institution:
Vertex Pharmaceuticals (United States)
Observed institutions:
University of Notre Dame,
Scripps Research Institute,
Max Planck Institute of Experimental Medicine,
Scripps Clinic,
Vertex Pharmaceuticals (United States),
Massachusetts Institute of Technology
show all 6
OpenAlex ID:
A5113709781
Crystal Structure of the Hepatitis C Virus NS3 Protease Domain Complexed with a Synthetic NS4A Cofactor Peptide
1996
·
J.L Kim
, K.A Morgenstern
, et al.
·
Cell
·
727
PDF
Platinum-195 NMR kinetic and mechanistic studies of cis- and trans-diamminedichloroplatinum(II) binding to DNA
1990
·
Daniel P. Bancroft
, Christopher A. Lepre
, et al.
·
Journal of the American Chemical Society
·
477
Theory and Applications of NMR-Based Screening in Pharmaceutical Research
2004
·
Christopher A. Lepre
, Jonathan M. Moore
, et al.
·
Chemical Reviews
·
322
The SHAPES strategy: an NMR-based approach for lead generation in drug discovery
1999
·
Jasna Fejzo
, Christopher A Lepre
, et al.
·
Chemistry & Biology
·
272
PDF
Crystal Structure of the Ectodomain Complex of the CGRP Receptor, a Class-B GPCR, Reveals the Site of Drug Antagonism
2010
·
Ernst ter Haar
, Christopher M. Koth
, et al.
·
Structure
·
189
PDF
High-resolution solution structure of reduced French bean plastocyanin and comparison with the crystal structure of poplar plastocyanin
1991
·
Jonathan M. Moore
, Christopher A. Lepre
, et al.
·
Journal of Molecular Biology
·
106
Interaction of Platinum Antitumor Compounds with DNA
1990
·
C. A. Lepre
, S. J. Lippard
·
Nucleic acids and molecular biology
·
104
Crystal Structure of the P38α-MAPKAP Kinase 2 Heterodimer
2007
·
Ernst ter Haar
, Prakash Prabakhar
, et al.
·
Journal of Biological Chemistry
·
100
PDF
Nuclear Magnetic Resonance-Based Approaches for Lead Generation in Drug Discovery
2002
·
Jeffrey W. Peng
, Christopher A. Lepre
, et al.
·
Methods in enzymology on CD-ROM/Methods in enzymology
·
74
Synthesis and characterization of trans-diamminedichloroplatinum(II) adducts of d(CCTCGAGTCTCC).cntdot.d(GGAGACTCGAGG)
1990
·
Christopher A. Lepre
, Laurent Chassot
, et al.
·
Biochemistry
·
74
15N NMR Relaxation Studies of the FK506 Binding Protein: Dynamic Effects of Ligand Binding and Implications for Calcineurin Recognition
1994
·
Jya-Wei Cheng
, Christopher A. Lepre
, et al.
·
Biochemistry
·
69
Microdrop screening: A rapid method to optimize solvent conditions for NMR spectroscopy of proteins
1998
·
Christopher A. Lepre
, Jonathan M. Moore
·
Journal of Biomolecular NMR
·
63
Library design for NMR-based screening
2001
·
Christopher A. Lepre
·
Drug Discovery Today
·
62
Practical Aspects of NMR-Based Fragment Screening
2011
·
Christopher A. Lepre
·
Methods in enzymology on CD-ROM/Methods in enzymology
·
60
Application of NMR Screening in Drug Discovery
2003
·
Jasna Fejzo
, Christopher Lepre
, et al.
·
Current Topics in Medicinal Chemistry
·
56
Nitrogen-15 NMR relaxation studies of the FK506 binding protein: Backbone dynamics of the uncomplexed receptor
1993
·
Jya Wei Cheng
, Christopher A. Lepre
, et al.
·
Biochemistry
·
55
Refolding and Characterization of a Soluble Ectodomain Complex of the Calcitonin Gene-Related Peptide Receptor
2010
·
Christopher M. Koth
, Norzehan Abdul-Manan
, et al.
·
Biochemistry
·
44
Applications of SHAPES Screening in Drug Discovery
2002
·
Christopher A. Lepre
, Jeffrey Peng
, et al.
·
Combinatorial Chemistry & High Throughput Screening
·
43
Synthesis and proton NMR spectroscopic characterization of trans-[Pt(NH3)2[d(ApGpGpCpCpT)-N7-A(1),N7-G(3)]]
1987
·
Christopher A. Lepre
, Kenneth G. Strothkamp
, et al.
·
Biochemistry
·
39
Solution structure of FK506 bound to FKBP‐12
1992
·
Christopher A. Lepre
, John A. Thomson
, et al.
·
FEBS Letters
·
37
Fragment-Based Discovery of Dual JC Virus and BK Virus Helicase Inhibitors
2016
·
Dominique Bonafoux
, Suganthini Nanthakumar
, et al.
·
Journal of Medicinal Chemistry
·
30
ChemInform Abstract: 195Pt NMR Kinetic and Mechanistic Studies of cis‐ and trans‐Diamminedichloroplatinum(II) Binding to DNA.
1990
·
D. P. BANCROFT
, C. A. LEPRE
, et al.
·
ChemInform
·
25
Leveraging structural approaches: applications of NMR-based screening and X-ray crystallography for inhibitor design
2003
·
Jonathan Moore
, Norzehan Abdul-Manan
, et al.
·
Journal of Synchrotron Radiation
·
24
PDF
Dynamics of a receptor-bound ligand by heteronuclear NMR: FK506 bound to FKBP-12
1993
·
Christopher A. Lepre
, Jya Wei Cheng
, et al.
·
Journal of the American Chemical Society
·
17
Fragment-based drug discovery using the SHAPES method
2007
·
Christopher Lepre
·
Expert Opinion on Drug Discovery
·
16
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Works count:
37
Citation count:
3,135
H-index:
23
I10-index:
28
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