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Holger Jaeschke

Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas
2016 · Davide Calebiro, Elisa S. Grassi, et al. · Journal of Clinical Investigation · 91
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Evaluation of Small-Molecule Modulators of the Luteinizing Hormone/Choriogonadotropin and Thyroid Stimulating Hormone Receptors: Structure−Activity Relationships and Selective Binding Patterns
2006 · Susanna Moore, Holger Jaeschke, et al. · Journal of Medicinal Chemistry · 83
Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort
2016 · Christoffer Löf, Konrad Patyra, et al. · Thyroid · 81
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Contacts between Extracellular Loop Two and Transmembrane Helix Six Determine Basal Activity of the Thyroid-stimulating Hormone Receptor
2006 · Gunnar Kleinau, Maren Claus, et al. · Journal of Biological Chemistry · 62
The hinge region: an important receptor component for GPHR function
2009 · Sandra Mueller, Holger Jaeschke, et al. · Trends in Endocrinology and Metabolism · 54
Principles and Determinants of G-Protein Coupling by the Rhodopsin-Like Thyrotropin Receptor
2010 · Gunnar Kleinau, Holger Jaeschke, et al. · PLoS ONE · 53
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Extended Hormone Binding Site of the Human Thyroid Stimulating Hormone Receptor
2008 · Sandra Mueller, Gunnar Kleinau, et al. · Journal of Biological Chemistry · 46
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Evidence for cooperative signal triggering at the extracellular loops of the TSH receptor
2008 · Gunnar Kleinau, Holger Jaeschke, et al. · The FASEB Journal · 45
Somatic mutations in 33 benign and malignant hot thyroid nodules in children and adolescents
2014 · Markus Eszlinger, Marek Niedziela, et al. · Molecular and Cellular Endocrinology · 38
The Superagonistic Activity of Bovine Thyroid-stimulating Hormone (TSH) and the Human TR1401 TSH Analog Is Determined by Specific Amino Acids in the Hinge Region of the Human TSH Receptor
2009 · Sandra Mueller, Gunnar Kleinau, et al. · Journal of Biological Chemistry · 38
A Hydrophobic Cluster in the Center of the Third Extracellular Loop Is Important for Thyrotropin Receptor Signaling
2005 · Maren Claus, Holger Jaeschke, et al. · Endocrinology · 35
Significance of Ectodomain Cysteine Boxes 2 and 3 for the Activation Mechanism of the Thyroid-stimulating Hormone Receptor
2006 · Sandra Mueller, Gunnar Kleinau, et al. · Journal of Biological Chemistry · 34
Defining Structural and Functional Dimensions of the Extracellular Thyrotropin Receptor Region
2011 · Gunnar Kleinau, Sandra Mueller, et al. · Journal of Biological Chemistry · 27
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Cases of Borderline In Vitro Constitutive Thyrotropin Receptor Activity: How to Decide Whether a Thyrotropin Receptor Mutation Is Constitutively Active or Not?
2009 · Sandra Mueller, Hulya Ilıksu Gozu, et al. · Thyroid · 23
Shared Sporadic and Somatic Thyrotropin Receptor Mutations Display More Active In Vitro Activities than Familial Thyrotropin Receptor Mutations
2010 · Julia Lueblinghoff, Markus Eszlinger, et al. · Thyroid · 21
Influence of the Hinge Region and Its Adjacent Domains on Binding and Signaling Patterns of the Thyrotropin and Follitropin Receptor
2014 · Jörg Schaarschmidt, Sandra Huth, et al. · PLoS ONE · 20
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Hyperthyroidism and Papillary Thyroid Carcinoma in Thyrotropin Receptor D633H Mutant Mice
2018 · Holger Jaeschke, Henriette Undeutsch, et al. · Thyroid · 19
Rearrangement of the Extracellular Domain/Extracellular Loop 1 Interface Is Critical for Thyrotropin Receptor Activation
2016 · Joerg Schaarschmidt, Marcus B.M. Nagel, et al. · Journal of Biological Chemistry · 18
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Lack of in vitro constitutive activity for four previously reported TSH receptor mutations identified in patients with nonautoimmune hyperthyroidism and hot thyroid carcinomas
2010 · Holger Jaeschke, Sandra Mueller, et al. · Clinical Endocrinology · 14
The Hinge Region of the TSH Receptor Stabilizes Ligand Binding and Determines Different Signaling Profiles of Human and Bovine TSH
2011 · Holger Jaeschke, Jörg Schaarschmidt, et al. · Endocrinology · 13
Identification of Novel TSH Interaction Sites by Systematic Binding Analysis of the TSHR Hinge Region
2011 · Sandra Mueller, Mariusz W. Szkudlinski, et al. · Endocrinology · 13
Congenital Hypothyroidism and Hyperthyroidism Alters Adrenal Gene Expression, Development, and Function
2022 · Konrad Patyra, Christoffer Löf, et al. · Thyroid · 12
Current Standards, Variations, and Pitfalls for the Determination of Constitutive TSHR Activity In Vitro
2010 · Sandra Mueller, Holger Jaeschke, et al. · Methods in enzymology on CD-ROM/Methods in enzymology · 11
Partial thyrocyte‐specific Gα s deficiency leads to rapid‐onset hypothyroidism, hyperplasia, and papillary thyroid carcinoma‐like lesions in mice
2018 · Konrad Patyra, Holger Jaeschke, et al. · The FASEB Journal · 9
A Newly Discovered TSHR Variant (L665F) Associated With Nonautoimmune Hyperthyroidism in an Austrian Family Induces Constitutive TSHR Activation by Steric Repulsion Between TM1 and TM7
2014 · Holger Jaeschke, Joerg Schaarschmidt, et al. · The Journal of Clinical Endocrinology & Metabolism · 9
Works count: 30
Citation count: 873
H-index: 18
I10-index: 23
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