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Kazuki Hoshino

Observed names: Hoshino, Kazuki, K Hoshino, K. Hoshino
OpenAlex ID: A5113777779
Identification and Characterization of Inhibitors of Multidrug Resistance Efflux Pumps in Pseudomonas aeruginosa : Novel Agents for Combination Therapy
2001 · Olga Lomovskaya, Mark S. Warren, et al. · Antimicrobial Agents and Chemotherapy · 923
Structural basis for the inhibition of bacterial multidrug exporters
2013 · Ryosuke Nakashima, Keisuke Sakurai, et al. · Nature · 307
Impact of Siderophore Production on Pseudomonas aeruginosa Infections in Immunosuppressed Mice
2000 · Hiroyuki Takase, Hironobu Nitanai, et al. · Infection and Immunity · 279
Interplay between Efflux Pumps May Provide Either Additive or Multiplicative Effects on Drug Resistance
2000 · Angela Lee, Weimin Mao, et al. · Journal of Bacteriology · 272
Use of a Genetic Approach To Evaluate the Consequences of Inhibition of Efflux Pumps in Pseudomonas aeruginosa
1999 · Olga Lomovskaya, Angela Lee, et al. · Antimicrobial Agents and Chemotherapy · 219
Comparison of inhibition of Escherichia coli topoisomerase IV by quinolones with DNA gyrase inhibition
1994 · K Hoshino, A Kitamura, et al. · Antimicrobial Agents and Chemotherapy · 162
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: Highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate
2007 · Ken-ichi Yoshida, Kiyoshi Nakayama, et al. · Bioorganic & Medicinal Chemistry · 134
Antimicrobial activity of DU-6859, a new potent fluoroquinolone, against clinical isolates
1992 · K Sato, K Hoshino, et al. · Antimicrobial Agents and Chemotherapy · 122
Mechanism of differential activities of ofloxacin enantiomers
1996 · I Morrissey, K Hoshino, et al. · Antimicrobial Agents and Chemotherapy · 100
Requirement of the Pseudomonas aeruginosa tonB Gene for High-Affinity Iron Acquisition and Infection
2000 · Hiroyuki Takase, Hironobu Nitanai, et al. · Infection and Immunity · 89
Quinolone-resistant mutants of escherichia coli DNA topoisomerase IV parC gene
1996 · Y Kumagai, J I Kato, et al. · Antimicrobial Agents and Chemotherapy · 87
MexAB-OprM-Specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 1: Discovery and early strategies for lead optimization
2003 · Kiyoshi Nakayama, Yohei Ishida, et al. · Bioorganic & Medicinal Chemistry Letters · 86
Efflux pump inhibitors reduce the invasiveness of Pseudomonas aeruginosa
2009 · Yoichi Hirakata, Akira Kondo, et al. · International Journal of Antimicrobial Agents · 76
Inhibitory effects of quinolones on DNA gyrase of Escherichia coli and topoisomerase II of fetal calf thymus
1989 · K Hoshino, K Sato, et al. · Antimicrobial Agents and Chemotherapy · 70
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MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 3: Optimization of potency in the pyridopyrimidine series through the application of a pharmacophore model
2003 · Kiyoshi Nakayama, Haruko Kawato, et al. · Bioorganic & Medicinal Chemistry Letters · 67
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 6: Exploration of aromatic substituents
2006 · Ken-ichi Yoshida, Kiyoshi Nakayama, et al. · Bioorganic & Medicinal Chemistry · 64
In Vitro and In Vivo Antibacterial Activities of DC-159a, a New Fluoroquinolone
2007 · Kazuki Hoshino, Kazue Inoue, et al. · Antimicrobial Agents and Chemotherapy · 63
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 2: achieving activity in vivo through the use of alternative scaffolds
2003 · Kiyoshi Nakayama, Yohei Ishida, et al. · Bioorganic & Medicinal Chemistry Letters · 59
Contribution of the C-8 substituent of DU-6859a, a new potent fluoroquinolone, to its activity against DNA gyrase mutants of Pseudomonas aeruginosa
1995 · A Kitamura, K Hoshino, et al. · Antimicrobial Agents and Chemotherapy · 55
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety
2004 · Kiyoshi Nakayama, Noriko Kuru, et al. · Bioorganic & Medicinal Chemistry Letters · 51
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 5: Carbon-substituted analogues at the C-2 position
2005 · Ken-ichi Yoshida, Kiyoshi Nakayama, et al. · Bioorganic & Medicinal Chemistry · 50
Dual-targeting properties of the 3-aminopyrrolidyl quinolones, DC-159a and sitafloxacin, against DNA gyrase and topoisomerase IV: contribution to reducing in vitro emergence of quinolone-resistant Streptococcus pneumoniae
2008 · R. Okumura, T. Hirata, et al. · Journal of Antimicrobial Chemotherapy · 49
Significance of the methyl group on the oxazine ring of ofloxacin derivatives in the inhibition of bacterial and mammalian type II topoisomerases
1991 · K Hoshino, K Sato, et al. · Antimicrobial Agents and Chemotherapy · 46
Active efflux of ofloxacin by a highly quinolone-resistant strain of Proteus vulgaris
1991 · Hiroko Ishii, Kenichi Sato, et al. · Journal of Antimicrobial Chemotherapy · 39
Synthesis of a novel inhibitor against MRSA and VRE: Preparation from zerumbone ring opening material showing histidine-kinase inhibition
2006 · Takashi Kitayama, Risa Iwabuchi, et al. · Bioorganic & Medicinal Chemistry Letters · 25
Works count: 49
Citation count: 3,614
H-index: 25
I10-index: 29
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