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Brian P. Clarke

Crystal Structure of the IMP-1 Metallo β-Lactamase from Pseudomonas aeruginosa and Its Complex with a Mercaptocarboxylate Inhibitor: Binding Determinants of a Potent, Broad-Spectrum Inhibitor,
2000 · Néstor O. Concha, Cheryl A. Janson, et al. · Biochemistry · 309
The contribution of ecological genetics to evolutionary theory: detecting the direct effects of natural selection on particular polymorphic loci.
1975 · B Clarke · PubMed · 250
Extreme divergence of mitochondrial DNA within species of pulmonate land snails
1996 · D. Thomaz, A. Guiller, et al. · Proceedings of the Royal Society B Biological Sciences · 237
Characterization of the Glycosylation Profiles of Alzheimer's β-Secretase Protein Asp-2 Expressed in a Variety of Cell Lines
2001 · Joanne Charlwood, Colin Dingwall, et al. · Journal of Biological Chemistry · 96
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The genus Partula on Moorea: speciation in progress
1980 · J. Murray, B. Clarke · Proceedings of the Royal Society B Biological Sciences · 77
Second Generation of Hydroxyethylamine BACE-1 Inhibitors: Optimizing Potency and Oral Bioavailability
2008 · Nicolas Charrier, Brian Clarke, et al. · Journal of Medicinal Chemistry · 69
Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators
2010 · Simon E. Ward, Mark Harries, et al. · Journal of Medicinal Chemistry · 67
Evidence for Apostatic Selection by Predators using Olfactory Cues
1973 · I. D. SOANE, B. CLARKE · Nature · 60
BACE-1 inhibitors part 3: Identification of hydroxy ethylamines (HEAs) with nanomolar potency in cells
2008 · Paul Beswick, Nicolas Charrier, et al. · Bioorganic & Medicinal Chemistry Letters · 59
BACE-1 inhibitors part 2: Identification of hydroxy ethylamines (HEAs) with reduced peptidic character
2008 · Brian Clarke, Emmanuel Demont, et al. · Bioorganic & Medicinal Chemistry Letters · 58
The Legion Grid Portal
2002 · Anand Natrajan, Anh Nguyen‐Tuong, et al. · Concurrency and Computation Practice and Experience · 58
Second generation of BACE-1 inhibitors part 3: Towards non hydroxyethylamine transition state mimetics
2009 · Nicolas Charrier, Brian Clarke, et al. · Bioorganic & Medicinal Chemistry Letters · 55
Leaving Christianity
2017 · Brian Clarke, Stuart Macdonald · McGill-Queen's University Press eBooks · 53
Second generation of BACE-1 inhibitors. Part 1: The need for improved pharmacokinetics
2009 · Nicolas Charrier, Brian Clarke, et al. · Bioorganic & Medicinal Chemistry Letters · 49
Second generation of BACE-1 inhibitors part 2: Optimisation of the non-prime side substituent
2009 · Nicolas Charrier, Brian Clarke, et al. · Bioorganic & Medicinal Chemistry Letters · 49
BACE-1 inhibitors Part 1: Identification of novel hydroxy ethylamines (HEAs)
2008 · Brian Clarke, Emmanuel Demont, et al. · Bioorganic & Medicinal Chemistry Letters · 48
6-(Substituted methylene)penems, potent broad spectrum inhibitors of bacterial .BETA.-lactamase. III. Structure-activity relationships of the 5-membered heterocyclic derivatives.
1991 · I. BENNETT, N. J. P. BROOM, et al. · The Journal of Antibiotics · 47
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Some Contributions of Snails to the Development of Ecological Genetics
1978 · B. Clarke · Proceedings in life sciences · 47
Discrepancies in the estimation of gene flow in partula.
1988 · M S Johnson, B Clarke, et al. · Genetics · 43
Piety and Nationalism
1993 · Brian P. Clarke · McGill-Queen's University Press eBooks · 28
Studies on Cepaea VI. The spatial and temporal distribution of pheno-types in a colony of Cepaea nemoralis (L.)
1968 · B. Clarke, C. Diver, et al. · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 26
Changes of Gene Frequency in Cepaea Nemoralis Over Fifty Years
1978 · James A. Murray, Brian Clarke · 25
Piety and Nationalism: Lay Voluntary Associations and the Creation of an Irish-Catholic Community in Toronto, 1850-1895.
1995 · John Zucchi, Brian P. Clarke · The American Historical Review · 24
The relationship between crystallographic structure and luminescence in single crystals of acridine
1975 · Brian P. Clarke, John M. Thomas, et al. · Chemical Physics Letters · 22
Independence of genetic subdivison and variation for coil in Partula suturalis
1987 · M S Johnson, J Murray, et al. · Heredity · 20
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Works count: 64
Citation count: 2,019
H-index: 23
I10-index: 32
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