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Piet Hein van der Graaf

Observed names: Piet Graaf, Piet Hein Van Der Graaf, Piet Van Der Graaf, Piet Van der Graaf, Piet van der Graaf, van der Graaf, Piet
ORCID: 0000-0003-1314-3484
Observed ORCID: 0000-0003-1314-3484
OpenAlex ID: A5113984055
Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders
2005 · Tommy Pattij, Trynke R. De Jong, et al. · European Journal of Neuroscience · 166
Drug Disposition in Obesity: Toward Evidence-Based Dosing
2014 · Catherijne A.J. Knibbe, Margreke J.E. Brill, et al. · The Annual Review of Pharmacology and Toxicology · 129
Minimal brain PBPK model to support the preclinical and clinical development of antibody therapeutics for CNS diseases
2021 · Peter Bloomingdale, Suruchi Bakshi, et al. · Journal of Pharmacokinetics and Pharmacodynamics · 39
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Novel Selective Inhibitors of Neutral Endopeptidase for the Treatment of Female Sexual Arousal Disorder. Synthesis and Activity of Functionalized Glutaramides
2006 · David C. Pryde, Graham N. Maw, et al. · Journal of Medicinal Chemistry · 38
A New Minimal-Stress Freely-Moving Rat Model for Preclinical Studies on Intranasal Administration of CNS Drugs
2009 · Jasper Stevens, Ernst Suidgeest, et al. · Pharmaceutical Research · 28
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Novel selective inhibitors of neutral endopeptidase for the treatment of female sexual arousal disorder
2006 · David C. Pryde, Andrew S. Cook, et al. · Bioorganic & Medicinal Chemistry · 23
Online solid phase extraction with liquid chromatography–tandem mass spectrometry to analyze remoxipride in small plasma-, brain homogenate-, and brain microdialysate samples
2010 · Jasper Stevens, Dirk-Jan van den Berg, et al. · Journal of Chromatography B · 17
Modulation of agonist responses at the A1 adenosine receptor by an irreversible antagonist, receptor–G protein uncoupling and by the G protein activation state
2002 · Anna Lorenzen, Margot W Beukers, et al. · Biochemical Pharmacology · 17
Multivariate calibration of reversed-phase chromatographic systems. Some designs based on three-way data analysis
1990 · Age K. Smilde, Piet Hein van der Graaf, et al. · Analytica Chimica Acta · 17
In vitro and in silico analysis of the effects of D 2 receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations
2018 · Wilhelmus E A de Witte, Joost W Versfelt, et al. · British Journal of Pharmacology · 15
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The Discovery of Small Molecule Inhibitors of Neutral Endopeptidase. Structure–Activity Studies on Functionalized Glutaramides
2005 · Graham N. Maw, Alan Stobie, et al. · Chemical Biology & Drug Design · 7
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A modeling informed quantitative approach to salvage clinical trials interrupted due to COVID‐19
2020 · Hugo Geerts, Piet van der Graaf · Alzheimer s & Dementia Translational Research & Clinical Interventions · 6
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A quantitative systems pharmacology model for simulating OFF-Time in augmentation trials for Parkinson’s disease: application to preladenant
2022 · Rachel Rose, Emma Mitchell, et al. · Journal of Pharmacokinetics and Pharmacodynamics · 5
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The Pharmacodynamic Effects of a Dopamine–Somatostatin Chimera Agonist on the Cardiovascular System
2019 · Michiel Joost van Esdonk, Jasper Stevens, et al. · Journal of Cardiovascular Pharmacology · 5
Exploring treatment guidelines for amyloid therapies in Alzheimer’s Disease Using Predictive Quantitative System Pharmacology Modeling
2023 · Hugo Geerts, Silke Bergeler, et al. · Alzheimer s & Dementia · 4
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Blood‐Based Biomarkers of Quinpirole Pharmacology: Cluster‐Based PK / PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain
2019 · Willem J. van den Brink, Robin Hartman, et al. · CPT Pharmacometrics & Systems Pharmacology · 2
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Correlation between affinity and efficacy
2003 · Piet van der Graaf · Trends in Pharmacological Sciences · 2
Quantitative Systems Pharmacology approaches for Development of Host-Directed Therapies against Mycobacterium tuberculosis infections
2024 · Krina Mehta, Herman Spaink, et al. · 1
Mechanistic modeling of tau biomarkers for amyloid load. A Quantitative Systems Pharmacology study of amyloid‐tau interaction.
2023 · Hugo Geerts, Silke Bergeler, et al. · Alzheimer s & Dementia · 1
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Faculty Opinions recommendation of Mechanistic models versus machine learning, a fight worth fighting for the biological community?
2018 · Piet van der Graaf · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 1
Editorial Special Supplement of the European Journal of Pharmaceutical Sciences on the occasion of the retirement of Professor Meindert Danhof as Professor of Pharmacology at Leiden University
2017 · Koos Burggraaf, Douwe Breimer, et al. · European Journal of Pharmaceutical Sciences · 1
Quantitative Systems Pharmacology Analysis of Amyloid Aggregation and Hippocampal Atrophy Trajectories in Alzheimer’s Disease by APOE4 Genotype and Valiltramiprosate/ALZ-801 Treatment
2026 · John A. Hey, Hugo Geerts, et al. · Research Square
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Abstract 1238: ISB 2001, a BCMA and CD38 dual targeting T cell engager, demonstrates superior cytotoxicity relative to teclistamab in the samples of patient relapsing from CD38 and BCMA targeted immunotherapies
2024 · Laura Carretero-Iglesia, Maria Pihlgren, et al. · Cancer Research
Development of a quantitative systems pharmacology (QSP) model to support dose optimization of DS-1103a (anti SIRPa antibody) in combination with trastuzumab deruxtecan in patients with cancer.
2023 · Yougan Cheng, Pradeep Vuppala, et al. · Journal of Clinical Oncology
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Faculty Opinions recommendation of Reproducibility in systems biology modelling.
2022 · Piet van der Graaf · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Works count: 51
Citation count: 524
H-index: 10
I10-index: 10
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