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Geoffrey Del Rosario

Observed name: Geoffrey del Rosario
Institution: Genentech
OpenAlex ID: A5114045875
Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity
2019 · Thomas H. Pillow, Pragya Adhikari, et al. · ChemMedChem · 216
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy
2021 · Peter S. Dragovich, Thomas H. Pillow, et al. · Journal of Medicinal Chemistry · 175
Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates
2016 · Thomas H. Pillow, Jack D. Sadowsky, et al. · Chemical Science · 142
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Modulating Antibody–Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification
2018 · Dian Su, Katherine R. Kozak, et al. · Bioconjugate Chemistry · 83
Bridging the Gap between Preclinical and Clinical Studies Using Pharmacokinetic–Pharmacodynamic Modeling: An Analysis of GDC-0973, a MEK Inhibitor
2012 · Harvey Wong, Laurent Vernillet, et al. · Clinical Cancer Research · 80
Modulating Therapeutic Activity and Toxicity of Pyrrolobenzodiazepine Antibody–Drug Conjugates with Self-Immolative Disulfide Linkers
2017 · Thomas H. Pillow, Melissa Schutten, et al. · Molecular Cancer Therapeutics · 72
A homogeneous high-DAR antibody–drug conjugate platform combining THIOMAB antibodies and XTEN polypeptides
2022 · Neelie Zacharias, Vladimir N. Podust, et al. · Chemical Science · 69
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An Anti–CLL-1 Antibody–Drug Conjugate for the Treatment of Acute Myeloid Leukemia
2018 · Bing Zheng, Shang-Fan Yu, et al. · Clinical Cancer Research · 66
Development of Efficient Chemistry to Generate Site-Specific Disulfide-Linked Protein– and Peptide–Payload Conjugates: Application to THIOMAB Antibody–Drug Conjugates
2017 · Jack D. Sadowsky, Thomas H. Pillow, et al. · Bioconjugate Chemistry · 58
High-Resolution Accurate-Mass Mass Spectrometry Enabling In-Depth Characterization of in Vivo Biotransformations for Intact Antibody-Drug Conjugates
2017 · Jintang He, Dian Su, et al. · Analytical Chemistry · 58
Calicheamicin Antibody–Drug Conjugates with Improved Properties
2021 · Breanna S. Vollmar, Chris Frantz, et al. · Molecular Cancer Therapeutics · 37
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Stabilizing a Tubulysin Antibody–Drug Conjugate To Enable Activity Against Multidrug-Resistant Tumors
2017 · Leanna R. Staben, Shang-Fan Yu, et al. · ACS Medicinal Chemistry Letters · 30
Front Cover: Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity (ChemMedChem 1/2020)
2020 · Thomas H. Pillow, Pragya Adhikari, et al. · ChemMedChem · 22
Antibody–Drug Conjugates Derived from Cytotoxic seco-CBI-Dimer Payloads Are Highly Efficacious in Xenograft Models and Form Protein Adducts In Vivo
2019 · Dian Su, Jinhua Chen, et al. · Bioconjugate Chemistry · 21
An Anti–CD22- seco -CBI-Dimer Antibody–Drug Conjugate (ADC) for the Treatment of Non-Hodgkin Lymphoma That Provides a Longer Duration of Response than Auristatin-Based ADCs in Preclinical Models
2020 · Shang-Fan Yu, Donna W. Lee, et al. · Molecular Cancer Therapeutics · 13
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Antibody-Mediated Delivery of BRM/BRG1 Protein Degraders Affords Strong Antitumor Efficacy in Multiple BRM-Dependent Non-Small Cell Lung Cancer Xenograft Models
2026 · Summer A. Baker Dockrey, Pravin Chandra, et al. · Journal of Medicinal Chemistry · 4
Measurement of specific and nonspecific tissue uptake of antibodies in tumor by SPECT imaging and nonlinear compartmental modeling
2025 · Nicholas Cho, Jason Ho, et al. · EJNMMI Research · 2
A Critical Role for PIM2 Kinase in Multiple Myeloma Through NF-κB Activation
2011 · Veerendra Munugalavadla, Leanne Berry, et al. · Blood · 1
1453: Lonidamine Reduces Prostate Weight in Rodents and is Accompanied by Apoptosis and Disruption of the Epithelial Cell Layer
2006 · W. Steve Ammons, Tatyana Lukoyanova, et al. · The Journal of Urology · 1
Investigation of the pharmacokinetics, metabolism, and clearance pathways of a heterobifunctional BRM degrader delivered by a TROP2-targeting antibody
2026 · Joyce Liu, Shu Chen, et al. · Drug Metabolism and Disposition
Abstract 2577: Analyzing specific and nonspecific tissue uptake of antibodies by SPECT imaging and non-linear compartmental modeling
2024 · Nicholas Cho, Phillip Spinosa, et al. · Cancer Research
Determining the conditions for robust acidoCEST MRI to measure extracellular pH in tumors in vivo
2023 · Rohan Virgincar, Kai Barck, et al. · Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition
Supplementary Data from Calicheamicin Antibody–Drug Conjugates with Improved Properties
2023 · Breanna S. Vollmar, Chris Frantz, et al.
Supplementary Data from Calicheamicin Antibody–Drug Conjugates with Improved Properties
2023 · Breanna S. Vollmar, Chris Frantz, et al.
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Data from Calicheamicin Antibody–Drug Conjugates with Improved Properties
2023 · Breanna S. Vollmar, Chris Frantz, et al.
Works count: 54
Citation count: 1,149
H-index: 14
I10-index: 15
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