EGR-mediated STIM1-PMCA expression and function in T cell subsets
Description: EGR-MEDIATED STIM1-PMCA EXPRESSION AND FUNCTION IN T CELL SUBSETS – NARRATIVE STIM1-dependent Ca2+ signals represent the primary means of Ca2+ entry in T cells, with critical contributions to their activation. We have recently shown that, in addition to activating Ca2+ channels, STIM1 also inhibits the plasma membrane Ca2+ pump during T cell activation. The current proposal focuses on defining the molecular events that mediate this process and determining the impact of this new STIM1-mediated function on T cell- mediated immunity.
Funding type: research
Funder scheme: R01
Start date: 2016-03-01
End date: 2020-12-31
Investigator: JONATHAN A SOBOLOFF
Institution: TEMPLE UNIV OF THE COMMONWEALTH
Topic: Ion Channels and Receptors
Subfield: Sensory Systems
Field: Neuroscience
Domain: Life Sciences
Funded outputs count: 21
Funder award ID: R01GM117907
OpenAlex ID: G1185648512