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Lentiviral Gene Therapy of X-linked Agammaglobulinemia

Funding type: research
Funder scheme: R01
Start date: 2004-08-01
End date: 2009-09-22
Investigator: DAVID J RAWLINGS
Institution: SEATTLE CHILDREN'S HOSPITAL
Funded outputs count: 31
Funder award ID: R01HL075453
OpenAlex ID: G1513415236
The Autoimmune Risk Variant PTPN22 C1858T Alters B Cell Tolerance at Discrete Checkpoints and Differentially Shapes the Naive Repertoire
2017 · Genita Metzler, Xuezhi Dai, et al. · The Journal of Immunology · 24
Altered B cell signalling in autoimmunity
2017 · David J. Rawlings, Genita Metzler, et al. · Nature reviews. Immunology · 308
AI-17 Baff promotes systemic autoimmunity via taci-dependent activation of transitional B cells
2016 · Holly M Jacobs, Christopher D Thouvenel, et al. · Lupus Science & Medicine
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B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6
2016 · Shaun W. Jackson, Holly M. Jacobs, et al. · The Journal of Experimental Medicine · 205
Cutting Edge: BAFF Promotes Autoantibody Production via TACI-Dependent Activation of Transitional B Cells
2016 · Holly M Jacobs, Christopher D Thouvenel, et al. · The Journal of Immunology · 52
Correction
2016 · European Journal of Immunology
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BCR and co-receptor crosstalk facilitate the positive selection of self-reactive transitional B cells
2015 · Genita Metzler, Nikita S Kolhatkar, et al. · Current Opinion in Immunology · 21
Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome
2015 · Nikita S. Kolhatkar, Archana Brahmandam, et al. · The Journal of Experimental Medicine · 76
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B‐cell intrinsic TLR7 signals promote depletion of the marginal zone in a murine model of Wiskott–Aldrich syndrome
2015 · Nikita S. Kolhatkar, Nicole E. Scharping, et al. · European Journal of Immunology · 19
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The Tec Kinase–Regulated Phosphoproteome Reveals a Mechanism for the Regulation of Inhibitory Signals in Murine Macrophages
2015 · Giacomo Tampella, Hannah M Kerns, et al. · The Journal of Immunology · 19
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B cells take the front seat: dysregulated B cell signals orchestrate loss of tolerance and autoantibody production
2015 · Shaun W Jackson, Nikita S Kolhatkar, et al. · Current Opinion in Immunology · 59
CD4+ T Cells and CD40 Participate in Selection and Homeostasis of Peripheral B Cells
2014 · Marc A Schwartz, Nikita S Kolhatkar, et al. · The Journal of Immunology · 31
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Opposing Impact of B Cell–Intrinsic TLR7 and TLR9 Signals on Autoantibody Repertoire and Systemic Inflammation
2014 · Shaun W Jackson, Nicole E Scharping, et al. · The Journal of Immunology · 165
Progressive engineering of a homing endonuclease genome editing reagent for the murine X-linked immunodeficiency locus
2014 · Yupeng Wang, Iram F. Khan, et al. · Nucleic Acids Research · 9
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megaTALs: a rare-cleaving nuclease architecture for therapeutic genome engineering
2013 · Sandrine Boissel, Jordan Jarjour, et al. · Nucleic Acids Research · 173
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Novel fluorescent genome editing reporters for monitoring DNA repair pathway utilization at endonuclease-induced breaks
2013 · Ryan Kuhar, Kamila S. Gwiazda, et al. · Nucleic Acids Research · 66
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A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models
2013 · Xuezhi Dai, Richard G. James, et al. · Journal of Clinical Investigation · 177
Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells
2013 · Daniela A Bermejo, Shaun W Jackson, et al. · Nature Immunology · 236
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Coupling endonucleases with DNA end–processing enzymes to drive gene disruption
2012 · Michael T Certo, Kamila S Gwiazda, et al. · Nature Methods · 97
FcγRIIb and BAFF Differentially Regulate Peritoneal B1 Cell Survival
2012 · María C Amezcua Vesely, Marc Schwartz, et al. · The Journal of Immunology · 29
Integration of B cell responses through Toll-like receptors and antigen receptors
2012 · David J. Rawlings, Marc A. Schwartz, et al. · Nature reviews. Immunology · 338
Cutting Edge: Regulation of TLR4-Driven B Cell Proliferation by RP105 Is Not B Cell Autonomous
2012 · Jessica L Allen, Leah M Flick, et al. · The Journal of Immunology · 13
Differential impact of Toll-like receptor signaling on distinct B cell subpopulations
2011 · Almut Meyer-Bahlburg · Frontiers in bioscience · 40
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Tracking genome engineering outcome at individual DNA breakpoints
2011 · Michael T Certo, Byoung Y Ryu, et al. · Nature Methods · 309
Особенности Возрастной Динамики Качества Жизни Детей Раннего Возраста С Последствиями Перинатальных Поражений Центральной Нервной Системы
2011 · В. С. Ступак, В. И. Стародубов, et al. · CyberLeninK (CyberLeninka)
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