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Cytokines as Endogenous Mediators of Cancer Cachexia

Funding type: research
Funder scheme: R01
Start date: 1990-07-01
End date: 1995-04-30
Investigator: LYLE L MOLDAWER
Institution: UNIVERSITY OF FLORIDA
Funded outputs count: 28
Funder award ID: R01CA052108
OpenAlex ID: G8827484449
Interleukin-1 TNFα and Their Naturally Occurring Antagonists in Sepsis
2008 · Lyle L. Moldawer · Blood Purification · 32
Ciliary neurotrophic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response
1996 · N. J. Espat, T. Auffenberg, et al. · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · 88
Increased soluble interleukin-1 type II receptor concentrations in postoperative patients and in patients with sepsis syndrome.
1996 · J H Pruitt, M B Welborn, et al. · PubMed · 100
Monocyte Tumor Necrosis Factor Receptor Levels as a Predictor of Risk in Human Sepsis
1996 · Steve E. Calvano · Archives of Surgery · 48
A Role for Tumor Necrosis Factor- α in the Increased Mortality Associated with Vibrio Vulnificus Infection in the Presence of Hepatic Dysfunction
1996 · N. Joseph Espat, Troy Auffenberg, et al. · Annals of Surgery · 38
Correlation between acute physiology and chronic health evaluation (APACHE) III score and immunological parameters in critically ill patients with sepsis
1996 · M A Rogy, H S A Oldenburg, et al. · British journal of surgery · 28
Contribution of interleukin-1 to activation of coagulation and fibrinolysis, neutrophil degranulation, and the release of secretory- type phospholipase A2 in sepsis: studies in nonhuman primates after interleukin-1 alpha administration and during lethal bacteremia
1995 · PM Jansen, MA Boermeester, et al. · Blood · 98
Human tumor necrosis factor receptor (p55) and interleukin 10 gene transfer in the mouse reduces mortality to lethal endotoxemia and also attenuates local inflammatory responses.
1995 · M A Rogy, T Auffenberg, et al. · The Journal of Experimental Medicine · 102
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Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone and thyrotropin concentrations in man
1995 · T van der Poll, K J Van Zee, et al. · The Journal of Clinical Endocrinology & Metabolism · 85
Influence of IL-1 receptor blockade on the human response to endotoxemia.
1995 · K J Van Zee, S M Coyle, et al. · The Journal of Immunology · 68
Cytokine‐mediated alterations in host metabolism prevent nutritional repletion in cachectic cancer patients
1995 · N. Joseph Espat, Lyle L. Moldawer, et al. · Journal of Surgical Oncology · 86
Endotoxin-Induced Nitric Oxide Production in Pulmonary Artery Endothelial Cells Is Regulated by Cytokines
1994 · Juan C. Cendan · Archives of Surgery · 33
Tumour necrosis factor and cachexia: a current perspective
1994 · N.J. Espat, E.M. Copeland, et al. · Surgical Oncology · 90
Role and effect of TNF- alpha in experimental visceral leishmaniasis.
1994 · M C T Tumang, C Keogh, et al. · The Journal of Immunology · 132
Anti-Endotoxin Therapy in Primate Bacteremia with HA-1A and BPI
1994 · Michael A. Rogy, Lyle L. Moldawer, et al. · Annals of Surgery · 36
The role of bactericidal/permeability-increasing protein in the treatment of primate bacteremia and septic shock
1994 · Michael A. Rogy, Hester S. A. Oldenburg, et al. · Journal of Clinical Immunology · 25
Changes in Polymorphonuclear Leukocyte Surface and Plasma Bactericidal/Permeability-Increasing Protein and Plasma Lipopolysaccharide Binding Protein During Endotoxemia or Sepsis
1994 · Steve E. Calvano · Archives of Surgery · 73
Persistently elevated soluble tumor necrosis factor receptor and interleukin-1 receptor antagonist levels in critically ill patients.
1994 · M A Rogy, S M Coyle, et al. · PubMed · 93
The Metabolic Effects of Platelet-Activating Factor Antagonism in Endotoxemic Man
1994 · William A. Thompson · Archives of Surgery · 36
Cachexia and the acute‐phase protein response in inflammation are regulated by interleukin‐6
1993 · Hester S. A. Oldenburg, Michael A. Rogy, et al. · European Journal of Immunology · 153
Insulin-like growth factor-1 activity is inhibited by interleukin-1 alpha, tumor necrosis factor-alpha, and interleukin-6.
1993 · D D Lazarus, L L Moldawer, et al. · PubMed · 62
Comparison of Peripheral Blood Leukocyte Kinetics After Live Escherichia coli, Endotoxin, or Interleukin-1 α Administration Studies Using a Novel Interleukin-1 Receptor Antagonist
1993 · Arthur S. Hawes, Eva Fischer, et al. · Annals of Surgery · 29
Glucocorticoid therapy alters hormonal and cytokine responses to endotoxin in man
1993 · A E Barber, S M Coyle, et al. · The Journal of Immunology · 279
The Role of Cytokines in Cancer Cachexia
1992 · Lyle L. Moldawer, Michael A. Rogy, et al. · Journal of Parenteral and Enteral Nutrition · 107
Tumor necrosis factor soluble receptors circulate during experimental and clinical inflammation and can protect against excessive tumor necrosis factor alpha in vitro and in vivo.
1992 · K J Van Zee, T Kohno, et al. · Proceedings of the National Academy of Sciences · 840
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