Novel interaction between virus and host innate immune system
Description: Viral infection is a serious threat to our life and society. The innate immune system is a first line of deference against viral infection and is also required for the activation of adaptive immune response. We have been studying about the molecular mechanisms underlying the innate immune response during viral infection. We revealed that: 1) DDX60 played a crucial role in RIG-I-dependent and -independent antiviral activities in vivo; 2) Epidermal growth factor receptor (EGFR) mediated phosphorylation of DDX60, thereby attenuating DDX60 antiviral function; 3) The Zyxin protein stabilized the interaction between RIG-I and its adaptor MAVS and promoted RIG-I-mediated type I interferon production; 4) Extracellular vesicles were required for the innate immune response to hepatitis B virus. These findings elucidated novel molecular mechanisms of the innate immune responses against viral infection.
Amount: ¥4,940,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Start date: 2015-04-01
End date: 2018-03-31
Investigator: HIROYUKI OSHIUMI
Institution: Kumamoto University
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Funded outputs count: 26
Funder award ID: 15K08517
OpenAlex ID: G1887800256