Epitranscriptomics of the aging lung
Description: PROJECT NARRATIVE Aging associates with changes in molecular features in the lung and understanding the normal ranges of age- related variability may inform insights into normal lung biology and resilience. Investigating global RNA methylation in lung tissue may uncover new mechanisms underlying differences for age-related disparities in lung health, especially differences by sex and race. Modeling RNA methylation together with genetic variation and gene expression may highlight targetable new pathways to consider for maintaining respiratory health in the later decades of life.
Funding type: research
Funder scheme: R21
Start date: 2021-01-01
End date: 2023-12-31
Investigator: DAWN L DEMEO
Institution: BRIGHAM AND WOMEN'S HOSPITAL
Funded outputs count: 7
Funder award ID: R21HL156122
OpenAlex ID: G1908491380