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Cellular Mechanisms of Antidepressant Action

Funding type: research
Funder scheme: R37
Start date: 2003-05-07
End date: 2018-01-31
Investigator: RENE HEN
Institution: NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
Funded outputs count: 60
Funder award ID: R37MH068542
OpenAlex ID: G1908589138
A rare variant in GPR156 associated with depression in a Mennonite pedigree causes habenula hyperactivity and stress sensitivity in mice
2025 · Bradley R. Miller, Claudia Gonzaga-Jauregui, et al. · Proceedings of the National Academy of Sciences · 3
Adult-born granule cells facilitate remapping of spatial and non-spatial representations in the dentate gyrus
2023 · Sebnem N. Tuncdemir, Andres D. Grosmark, et al. · Neuron · 26
Adult born hippocampal granule cells promote pattern separation by bidirectionally modulating the remapping of place and cue cells
2022 · Sebnem N. Tuncdemir, Andres D. Grosmark, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Contribution of the Opioid System to the Antidepressant Effects of Fluoxetine
2022 · Elena Carazo-Arias, Phi T. Nguyen, et al. · Biological Psychiatry · 19
Parallel Processing of Sensory Cue and Spatial Information in the Dentate Gyrus
2021 · Sebnem N. Tuncdemir, Andres D. Grosmark, et al. · Cell Reports · 42
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Adult neurogenesis augmentation attenuates anhedonia and HPA axis dysregulation in a mouse model of chronic stress and depression
2020 · Hoda Eliwa, Bruno Brizard, et al. · Psychoneuroendocrinology · 73
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Contextual fear memory retrieval by correlated ensembles of ventral CA1 neurons
2020 · Jessica C. Jimenez, Jack E. Berry, et al. · Nature Communications · 162
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A Distributed Neural Code in the Dentate Gyrus and in CA1
2020 · Fabio Stefanini, Lyudmila Kushnir, et al. · Neuron · 169
Contributions of adult neurogenesis to dentate gyrus network activity and computations
2019 · Sebnem Nur Tuncdemir, Clay Orion Lacefield, et al. · Behavioural Brain Research · 97
Faculty Opinions recommendation of Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus.
2019 · Hanns Möhler · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
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Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus
2019 · Victor M. Luna, Christoph Anacker, et al. · Science · 181
Functional Interrogation of a Depression-Related Serotonergic Single Nucleotide Polymorphism, rs6295, Using a Humanized Mouse Model
2019 · Ashley M. Cunningham, Tabia L. Santos, et al. · ACS Chemical Neuroscience · 16
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Hippocampal neurogenesis confers stress resilience by inhibiting the ventral dentate gyrus
2018 · Christoph Anacker, Victor M. Luna, et al. · Nature · 606
Anxiety Cells in a Hippocampal-Hypothalamic Circuit
2018 · Jessica C. Jimenez, Katy Su, et al. · Neuron · 621
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Adult hippocampal neurogenesis and cognitive flexibility — linking memory and mood
2017 · Christoph Anacker, René Hen · Nature reviews. Neuroscience · 1,015
Serotonin receptors in depression: from A to B
2017 · Katherine M. Nautiyal, René Hen · F1000Research · 173
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A Lack of Serotonin 1B Autoreceptors Results in Decreased Anxiety and Depression-Related Behaviors
2016 · Katherine M Nautiyal, Laurent Tritschler, et al. · Neuropsychopharmacology · 68
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GluN2B-Containg NMDA Receptors on Adult-Born Granule Cells Contribute to the Antidepressant Action of Fluoxetine
2016 · Lindsay Tannenholz, René Hen, et al. · Frontiers in Neuroscience · 15
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Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding
2016 · Nathan B. Danielson, Patrick Kaifosh, et al. · Neuron · 352
Activation of local inhibitory circuits in the dentate gyrus by adult‐born neurons
2015 · Liam J. Drew, Mazen A. Kheirbek, et al. · Hippocampus · 169
5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response
2015 · Benjamin Adam Samuels, Christoph Anacker, et al. · Nature Neuroscience · 200
Loss of Striatonigral GABAergic Presynaptic Inhibition Enables Motor Sensitization in Parkinsonian Mice
2015 · Anders Borgkvist, Elizabeth M. Avegno, et al. · Neuron · 76
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Experience-Dependent Regulation of Dentate Gyrus Excitability by Adult-Born Granule Cells
2015 · Eun Hye Park, Nesha S. Burghardt, et al. · Journal of Neuroscience · 76
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Running rescues a fear-based contextual discrimination deficit in aged mice
2015 · Melody V. Wu, Victor M. Luna, et al. · Frontiers in Systems Neuroscience · 48
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Functional Differentiation of Adult-Born Neurons along the Septotemporal Axis of the Dentate Gyrus: Figure 1.
2015 · Melody V. Wu, Amar Sahay, et al. · Cold Spring Harbor Perspectives in Biology · 64
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