Dual Leucine Zipper Kinase (DLK) as a Mediator of Retinal Ganglion Cell Injury
Description: PUBLIC HEALTH RELEVANCE: Through high content and siRNA screening programs we have identified the protein kinase DLK as playing an important role in RGC death following injury. Inhibition of DLK provides a potential mechanism to promote RGC survival in glaucoma and in other forms of optic nerve disease. In this application, we propose to determine the ability of DLK inhibition to promote RGC survival in an animal model of glaucoma, study the mechanism of DLK regulation and action, and develop more selective DLK inhibitors.
Funder: National Eye Institute
Funding type: research
Funder scheme: R01
Start date: 2013-09-01
End date: 2018-08-31
Investigator: DONALD J. ZACK
Institution: JOHNS HOPKINS UNIVERSITY
Funded outputs count: 16
Funder award ID: R01EY023754
OpenAlex ID: G1908666086