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Antiviral lectins as microbicides

Funding type: research
Funder scheme: R01
Start date: 2008-04-15
End date: 2012-12-31
Investigator: KENNETH E PALMER
Institution: UNIVERSITY OF LOUISVILLE
Funded outputs count: 21
Funder award ID: R01AI076169
OpenAlex ID: G1909027151
A topical rectal douche product containing Q-Griffithsin does not disrupt the epithelial border or alter CD4+ cell distribution in the human rectal mucosa
2023 · Mathias Franzén Boger, Nora Benhach, et al. · Scientific Reports · 4
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Antiviral lectin Q-Griffithsin suppresses fungal infection in murine models of vaginal candidiasis
2022 · Henry W. Nabeta, Amanda B. Lasnik, et al. · Frontiers in Cellular and Infection Microbiology · 12
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Preformulation Characterization of Griffithsin, a Biopharmaceutical Candidate for HIV Prevention
2021 · Lindsay F. Kramzer, Krystal T. Hamorsky, et al. · AAPS PharmSciTech · 15
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Characterization of the hypersensitive response‐like cell death phenomenon induced by targeting antiviral lectin griffithsin to the secretory pathway
2018 · Bo Min Kim, Hester Catharina Therese Lotter‐Stark, et al. · Plant Biotechnology Journal · 13
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Pharmacokinetics of the Antiviral Lectin Griffithsin Administered by Different Routes Indicates Multiple Potential Uses
2016 · Christopher Barton, J. Kouokam, et al. · Viruses · 43
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Studies in a Murine Model Confirm the Safety of Griffithsin and Advocate Its Further Development as a Microbicide Targeting HIV-1 and Other Enveloped Viruses
2016 · Joseph Kouokam, Amanda Lasnik, et al. · Viruses · 41
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Bulk production of the antiviral lectin griffithsin
2015 · Joshua L. Fuqua, Krystal Hamorsky, et al. · Plant Biotechnology Journal · 38
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Improving the large scale purification of the HIV microbicide, griffithsin
2015 · Joshua L Fuqua, Valentine Wanga, et al. · BMC Biotechnology · 39
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Activity of and Effect of Subcutaneous Treatment with the Broad-Spectrum Antiviral Lectin Griffithsin in Two Laboratory Rodent Models
2013 · Christopher Barton, J. Calvin Kouokam, et al. · Antimicrobial Agents and Chemotherapy · 120
Griffithsin Protects Mice from Genital Herpes by Preventing Cell-to-Cell Spread
2013 · Briana Nixon, Martha Stefanidou, et al. · Journal of Virology · 111
Efficient Single Tobamoviral Vector-Based Bioproduction of Broadly Neutralizing Anti-HIV-1 Monoclonal Antibody VRC01 in Nicotiana benthamiana Plants and Utility of VRC01 in Combination Microbicides
2013 · Krystal Teasley Hamorsky, Tiffany W. Grooms-Williams, et al. · Antimicrobial Agents and Chemotherapy · 37
Combinations of Griffithsin with Other Carbohydrate-Binding Agents Demonstrate Superior Activity Against HIV Type 1, HIV Type 2, and Selected Carbohydrate-Binding Agent-Resistant HIV Type 1 Strains
2012 · Geoffrey Férir, Dana Huskens, et al. · AIDS Research and Human Retroviruses · 42
Synergistic anti-HIV-1 activity of griffithsin with tenofovir, maraviroc and enfuvirtide
2011 · Geoffrey Férir, Kenneth E Palmer, et al. · Retrovirology · 1
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Griffithsin Has Antiviral Activity against Hepatitis C Virus
2011 · Philip Meuleman, Anna Albecka, et al. · Antimicrobial Agents and Chemotherapy · 160
Investigation of Griffithsin's Interactions with Human Cells Confirms Its Outstanding Safety and Efficacy Profile as a Microbicide Candidate
2011 · Joseph Calvin Kouokam, Dana Huskens, et al. · PLoS ONE · 114
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Synergistic activity profile of griffithsin in combination with tenofovir, maraviroc and enfuvirtide against HIV-1 clade C
2011 · Geoffrey Férir, Kenneth E. Palmer, et al. · Virology · 56
Occluding the Mannose Moieties on Human Immunodeficiency Virus Type 1 gp120 with Griffithsin Improves the Antibody Responses to Both Proteins in Mice
2011 · Kaustuv Banerjee, Elizabeth Michael, et al. · AIDS Research and Human Retroviruses · 32
Degradation of naturally occurring and engineered antimicrobial peptides by proteases
2011 · Bernard J. Moncla, Kara Pryke, et al. · Advances in Bioscience and Biotechnology · 93
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Broad-SpectrumIn VitroActivity andIn VivoEfficacy of the Antiviral Protein Griffithsin against Emerging Viruses of the FamilyCoronaviridae
2009 · Barry R. O'Keefe, Barbara Giomarelli, et al. · Journal of Virology · 304
Scaleable manufacture of HIV-1 entry inhibitor griffithsin and validation of its safety and efficacy as a topical microbicide component
2009 · Barry R. O'Keefe, Fakhrieh Vojdani, et al. · Proceedings of the National Academy of Sciences · 262
Crystallographic, thermodynamic, and molecular modeling studies of the mode of binding of oligosaccharides to the potent antiviral protein griffithsin
2007 · Natasza E. Ziółkowska, Shilpa R. Shenoy, et al. · Proteins Structure Function and Bioinformatics · 66
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