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Dissociating Intrinsic and Extrinsic Motor Learning in Alzheimer's Disease

Description: The primary goal of this proposal is to determine whether intrinsically-based and extrinsically- based motor learning are differentially affected in Alzheimer's disease (AD). We plan on using specifically designed motor learning task to differentially measure these two forms of motor learning in AD patients compared to demographically matched controls as this may lead to the development mechanism-specific treatment for motor deficits in AD.
Funding type: research
Funder scheme: R01
Start date: 2012-09-30
End date: 2019-05-31
Investigator: MAURICE A SMITH
Institution: HARVARD UNIVERSITY
Funded outputs count: 16
Funder award ID: R01AG041878
OpenAlex ID: G1912646643
Tiny visual latencies can profoundly impair implicit sensorimotor learning
2025 · Alkis M. Hadjiosif, Y. Dajaj, et al. · Scientific Reports · 2
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The cerebellum acts as the analog to the medial temporal lobe for sensorimotor memory
2024 · Alkis M. Hadjiosif, Tricia L. Gibo, et al. · Proceedings of the National Academy of Sciences · 11
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Subtle Visual Latency Can Profoundly Impair Implicit Sensorimotor Learning
2024 · Alkis M. Hadjiosif, George Abraham, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 6
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A double dissociation between savings and long-term memory in motor learning
2023 · Alkis M. Hadjiosif, J. Ryan Morehead, et al. · PLoS Biology · 48
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Motor planning under uncertainty
2021 · Laith Alhussein, Maurice A Smith · eLife · 50
Motor planning under uncertainty
2021 · Laith Alhussein, Maurice A. Smith · bioRxiv (Cold Spring Harbor Laboratory) · 1
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Implicit adaptation compensates for erratic explicit strategy in human motor learning
2020 · Yohsuke R. Miyamoto, Shengxin Wang, et al. · Nature Neuroscience · 124
Dissociating effects of error size, training duration, and amount of adaptation on the ability to retain motor memories
2019 · Laith Alhussein, Eghbal A. Hosseini, et al. · Journal of Neurophysiology · 29
Temporal specificity of the initial adaptive response in motor adaptation
2017 · Wilsaan M. Joiner, Gary C. Sing, et al. · PLoS Computational Biology · 18
The Decay of Motor Memories Is Independent of Context Change Detection
2015 · Andrew E. Brennan, Maurice A. Smith · PLoS Computational Biology · 37
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Flexible Control of Safety Margins for Action Based on Environmental Variability
2015 · A. M. Hadjiosif, M. A. Smith · Journal of Neuroscience · 87
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Environmental Consistency Determines the Rate of Motor Adaptation
2014 · Luis Nicolas Gonzalez Castro, Alkis M. Hadjiosif, et al. · Current Biology · 117
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Temporal structure of motor variability is dynamically regulated and predicts motor learning ability
2014 · Howard G Wu, Yohsuke R Miyamoto, et al. · Nature Neuroscience · 681
The Generalization of Visuomotor Learning to Untrained Movements and Movement Sequences Based on Movement Vector and Goal Location Remapping
2013 · H. G. Wu, M. A. Smith · Journal of Neuroscience · 45
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The training schedule affects the stability, not the magnitude, of the interlimb transfer of learned dynamics
2013 · Wilsaan M. Joiner, Jordan B. Brayanov, et al. · Journal of Neurophysiology · 73
Motor Memory Is Encoded as a Gain-Field Combination of Intrinsic and Extrinsic Action Representations
2012 · Jordan B. Brayanov, Daniel Z. Press, et al. · Journal of Neuroscience · 99
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