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Mechanisms Underlying Neural Stem Cell Heterogeneity in the Adult Hippocampus

Description: Radial glia-like (RGL) cells exhibit significant heterogeneity in their behavior to act as neural stem cells in the adult hippocampus. This study investigates mechanisms underlying differences in RGL function including intrinsic potential and regulation by specific physiological and pathological conditions.
Funding type: research
Funder scheme: R00
Start date: 2015-06-15
End date: 2019-03-31
Investigator: MICHAEL BONAGUIDI
Institution: UNIVERSITY OF SOUTHERN CALIFORNIA
Funded outputs count: 13
Funder award ID: R00NS080913
OpenAlex ID: G19175229
Altered adult neurogenesis and gliogenesis in patients with mesial temporal lobe epilepsy
2022 · Aswathy Ammothumkandy, Kristine Ravina, et al. · Nature Neuroscience · 97
Early stem cell aging in the mature brain
2021 · Albina Ibrayeva, Maxwell Bay, et al. · Cell stem cell · 137
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Evaluation of Weng et al.: Leveraging Cell Type Correlations and Single-Cell Bioinformatics to Identify Progenitor Diversity and Lineage
2019 · Michael A. Bonaguidi · Cell stem cell
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The Presence of Neural Stem Cells and Changes in Stem Cell-Like Activity With Age in Mouse Spiral Ganglion Cells In Vivo and In Vitro
2018 · Byoung-San Moon, Aswathy Ammothumkandy, et al. · Clinical and Experimental Otorhinolaryngology · 9
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Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes
2018 · Gabriel B. Ferguson, Ben Van Handel, et al. · Nature Communications · 63
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Function and Dysfunction of Adult Hippocampal Neurogenesis in Regeneration and Disease
2017 · Lei Peng, Michael A. Bonaguidi · American Journal Of Pathology · 70
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Genome-wide analysis of facial skeletal regionalization in zebrafish
2017 · Amjad Askary, Pengfei Xu, et al. · Development · 48
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Diversity of Neural Precursors in the Adult Mammalian Brain
2016 · Michael A. Bonaguidi, Ryan P. Stadel, et al. · Cold Spring Harbor Perspectives in Biology · 51
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Heterogeneity of Radial Glia-Like Cells in the Adult Hippocampus
2016 · Elias Gebara, Michael Anthony Bonaguidi, et al. · Stem Cells · 133
Latent tri-lineage potential of adult hippocampal neural stem cells revealed by Nf1 inactivation
2015 · Gerald J Sun, Yi Zhou, et al. · Nature Neuroscience · 41
A septo-temporal molecular gradient of sfrp3 in the dentate gyrus differentially regulates quiescent adult hippocampal neural stem cell activation
2015 · Jiaqi Sun, Michael A. Bonaguidi, et al. · Molecular Brain · 31
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Pushing and Pulling on Adult Neural Stem Cells
2015 · Albina Ibrayeva, Michael A. Bonaguidi · Cell stem cell · 4
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Secreted Frizzled-Related Protein 3 Regulates Activity-Dependent Adult Hippocampal Neurogenesis
2013 · Mi-Hyeon Jang, Michael A. Bonaguidi, et al. · Cell stem cell · 200
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