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Modulation of Cardiac Repolarization

Description: Serious heart rhythm abnormalities are common causes of death and disability in the United States and worldwide. This research focuses on how genetic variation in key molecules controlling normal heart behavior makes people more or less susceptible to serious heart rhythm abnormalities.

Funder: National Heart, Lung, and Blood Institute

Funding type: research

Funder scheme: R01

Start date: 1994-08-01

End date: 2017-06-30

Investigator: DAN M RODEN

Institution: VANDERBILT UNIVERSITY MEDICAL CENTER

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

Funded outputs count: 98

Funder award ID: R01HL049989

OpenAlex ID: G191800368

Multiple mechanisms underlie increased cardiac late sodium current

2019 · Brett M. Kroncke, Tao Yang, et al. · Heart Rhythm · 10

Azithromycin Causes a Novel Proarrhythmic Syndrome

2017 · Zhenjiang Yang, Joseph K. Prinsen, et al. · Circulation Arrhythmia and Electrophysiology · 96

Contrasting Nav1.8 Activity in Scn10a −/− Ventricular Myocytes and the Intact Heart

2016 · Dina Myers Stroud, Tao Yang, et al. · Journal of the American Heart Association · 26

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting

2016 · Eva Wrobel, Ina Rothenberg, et al. · Nature Communications · 34

Pharmacogenetics of Potassium Channel Blockers

2016 · Dan M. Roden · Cardiac Electrophysiology Clinics · 20

Predicting drug‐induced QT prolongation and torsades de pointes

2015 · Dan M. Roden · The Journal of Physiology · 192

Pharmacology and Toxicology of Nav1.5-Class 1 Antiarrhythmic Drugs

2014 · Dan M. Roden · Cardiac Electrophysiology Clinics · 47

Early Time Dynamics of Strongly Coupled Ultracold Neutral Ca+ and Ca2+ Plasmas

2014 · Mary Lyon, Scott Bergeson · Digital Commons - USU (Utah State University) · 1

Screening for Acute I Kr Block Is Insufficient to Detect Torsades de Pointes Liability

2014 · Tao Yang, Young Wook Chun, et al. · Circulation · 163

The Brugada ECG and Schizophrenia

2014 · Dan M. Roden · Circulation Arrhythmia and Electrophysiology · 5

2014 · Dan M. Roden, Björn C. Knollmann · Circulation · 17

Personalized medicine to treat arrhythmias

2013 · Dan M Roden · Current Opinion in Pharmacology · 7

Applied Pharmacogenomics in Cardiovascular Medicine

2013 · Peter Weeke, Dan M. Roden · Annual Review of Medicine · 23

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

2013 · Connie R Bezzina, Julien Barc, et al. · Nature Genetics · 538

Stem Cell–Derived Cardiomyocytes as a Tool for Studying Proarrhythmia

2013 · Dan M. Roden, Charles C. Hong · Circulation · 14

An Allosteric Mechanism for Drug Block of the Human Cardiac Potassium Channel KCNQ1

2012 · Tao Yang, Jarrod A. Smith, et al. · Molecular Pharmacology · 16

Systems biology and cardiac arrhythmias

2012 · Andrew A Grace, Dan M Roden · The Lancet · 40

Blocking Scn10a Channels in Heart Reduces Late Sodium Current and Is Antiarrhythmic

2012 · Tao Yang, Thomas C. Atack, et al. · Circulation Research · 164

Increased late sodium current contributes to long QT-related arrhythmia susceptibility in female mice

2012 · John S. Lowe, Dina Myers Stroud, et al. · Cardiovascular Research · 43

Striking In Vivo Phenotype of a Disease-Associated Human SCN5A Mutation Producing Minimal Changes in Vitro

2011 · Hiroshi Watanabe, Tao Yang, et al. · Circulation · 139

Refining repolarization reserve

2011 · Dan M. Roden, Robert L. Abraham · Heart Rhythm · 48

Informatic and Functional Approaches to Identifying a Regulatory Region for the Cardiac Sodium Channel

2011 · Thomas C. Atack, Dina Myers Stroud, et al. · Circulation Research · 22

Genetic Testing in Subjects With No Clinical Abnormality

2010 · Dan M. Roden · Journal of the American College of Cardiology · 2

Sudden Cardiac Death Prediction and Prevention

2010 · Glenn I. Fishman, Sumeet S. Chugh, et al. · Circulation · 609

Drug-Induced Long QT Syndrome

2010 · Prince Kannankeril, Dan M. Roden, et al. · Pharmacological Reviews · 441