Award

Cell type signaling specificity of the neurodevelopmental disease-associated DYRK1A kinase

Description: PROJECT NARRATIVE Loss-of-function mutations in the DYRK1A gene have been tightly linked to neurodevelopmental disorders like autism spectrum disorders and intellectual disability. The research described in this proposal aims to uncover the specific mechanisms by which DYRK1A influences the function of immature neural stem and progenitor cells in the developing brain and their commitment to specific neural identities. The results of our studies will identify potential therapeutic entry points for neurodevelopmental disorders by defining intracellular signaling pathways regulated by DYRK1A that can be modulated to restore normal brain function.

Funder: National Institute of Mental Health

Funding type: research

Funder scheme: R56

Start date: 2021-07-01

End date: 2022-07-07

Investigator: GEORGIA PANAGIOTAKOS

Institution: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

Topic: Down syndrome and intellectual disability research

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

Funded outputs count: 2

Funder award ID: R56MH127075

OpenAlex ID: G1925010774

Calcium and activity-dependent signaling in the developing cerebral cortex

2022 · Arpana Arjun McKinney, Ralitsa Petrova, et al. · Development · 56

A matter of space and time: Emerging roles of disease-associated proteins in neural development

2021 · Georgia Panagiotakos, Sergiu P. Pasca · Neuron · 25