The role of SIK1 in myogenic differentiation and skeletal muscle repair
Description: The proposed studies will investigate the regulation and functions of an enzyme (SIK1) that responds to hormonal signals and regulates skeletal muscle differentiation. Therapeutic agents that activate this pathway prevent muscle atrophy in several human disease conditions, including disuse atrophy and muscular dystrophy, but these drugs have deleterious side effects. By understanding how SIK1 specifically functions in developing and adult skeletal muscle, we aim to establish it as a new molecular target for therapeutic agents that could be used to more specifically combat muscle degeneration with less side effects on other tissues.
Funding type: research
Funder scheme: R01
Start date: 2011-07-18
End date: 2017-06-30
Investigator: REBECCA L BERDEAUX
Institution: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 20
Funder award ID: R01AR059847
OpenAlex ID: G1925147126