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Resistance Suppression for P. Aeruginosa using Novel Combination Therapy Modeling

Funding type: research
Funder scheme: R01
Start date: 2008-08-01
End date: 2013-12-31
Investigator: GEORGE LOUIS DRUSANO
Institution: UNIVERSITY OF FLORIDA
Funded outputs count: 18
Funder award ID: R01AI079578
OpenAlex ID: G193674214
Suppression of Emergence of Resistance in Pathogenic Bacteria: Keeping Our Powder Dry, Part 1
2015 · G. L. Drusano, Arnold Louie, et al. · Antimicrobial Agents and Chemotherapy · 62
Suppression of Emergence of Resistance in Pathogenic Bacteria: Keeping Our Powder Dry, Part 2
2015 · G. L. Drusano, William Hope, et al. · Antimicrobial Agents and Chemotherapy · 53
Combination Treatment With Meropenem Plus Levofloxacin Is Synergistic Against Pseudomonas aeruginosa Infection in a Murine Model of Pneumonia
2014 · Arnold Louie, Weiguo Liu, et al. · The Journal of Infectious Diseases · 35
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Analysis of Combination Drug Therapy to Develop Regimens with Shortened Duration of Treatment for Tuberculosis
2014 · George L. Drusano, Michael Neely, et al. · PLoS ONE · 68
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Individualised antibiotic dosing for patients who are critically ill: challenges and potential solutions
2014 · Jason A Roberts, Mohd H Abdul-Aziz, et al. · The Lancet Infectious Diseases · 1,051
Interaction of Drug- and Granulocyte-Mediated Killing of Pseudomonas aeruginosa in a Murine Pneumonia Model
2014 · G. L. Drusano, W. Liu, et al. · The Journal of Infectious Diseases · 78
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Impact of Meropenem in Combination with Tobramycin in a Murine Model of Pseudomonas aeruginosa Pneumonia
2013 · Arnold Louie, Weiguo Liu, et al. · Antimicrobial Agents and Chemotherapy · 42
Resistance Emergence Mechanism and Mechanism of Resistance Suppression by Tobramycin for Cefepime for Pseudomonas aeruginosa
2011 · G. L. Drusano, Robert A. Bonomo, et al. · Antimicrobial Agents and Chemotherapy · 58
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Meropenem Penetration into Epithelial Lining Fluid in Mice and Humans and Delineation of Exposure Targets
2011 · G. L. Drusano, T. P. Lodise, et al. · Antimicrobial Agents and Chemotherapy · 44
Saturability of Granulocyte Kill of Pseudomonas aeruginosa in a Murine Model of Pneumonia
2011 · G. L. Drusano, B. VanScoy, et al. · Antimicrobial Agents and Chemotherapy · 73
Optimization of Aminoglycoside Therapy
2011 · G. L. Drusano, Arnold Louie · Antimicrobial Agents and Chemotherapy · 93
Penetration of Meropenem into Epithelial Lining Fluid of Patients with Ventilator-Associated Pneumonia
2011 · T. P. Lodise, F. Sorgel, et al. · Antimicrobial Agents and Chemotherapy · 121
Impact of Burden on Granulocyte Clearance of Bacteria in a Mouse Thigh Infection Model
2010 · G. L. Drusano, Christine Fregeau, et al. · Antimicrobial Agents and Chemotherapy · 85
The Combination of Meropenem and Levofloxacin Is Synergistic with Respect to both Pseudomonas aeruginosa Kill Rate and Resistance Suppression
2010 · Arnold Louie, Caroline Grasso, et al. · Antimicrobial Agents and Chemotherapy · 69
Impact of Different Carbapenems and Regimens of Administration on Resistance Emergence for Three Isogenic Pseudomonas aeruginosa Strains with Differing Mechanisms of Resistance
2010 · Arnold Louie, Adam Bied, et al. · Antimicrobial Agents and Chemotherapy · 43
Pharmacodynamics of Levofloxacin in a Murine Pneumonia Model of Pseudomonas aeruginosa Infection: Determination of Epithelial Lining Fluid Targets
2009 · Arnold Louie, Christine Fregeau, et al. · Antimicrobial Agents and Chemotherapy · 30
Differing Effects of Combination Chemotherapy with Meropenem and Tobramycin on Cell Kill and Suppression of Resistance of Wild-TypePseudomonas aeruginosaPAO1 and Its Isogenic MexAB Efflux Pump-Overexpressed Mutant
2009 · G. L. Drusano, Weiguo Liu, et al. · Antimicrobial Agents and Chemotherapy · 48
Impact of Short‐Course Quinolone Therapy on Susceptible and Resistant Populations ofStaphylococcus aureus
2008 · G. L. Drusano, W. Liu, et al. · The Journal of Infectious Diseases · 33
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