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Role of Food Intolerance and Protease on Pathophysiology of Irritable Bowel Syndrome

Description: Our aims were to determine whether camostat mesilate (600mg/day), a synthetic protease inhibitor, changes visceral pain sensitivity and gastrointestinal motility and whether these changes affect clinical symptom severity in patients with irritable bowel syndrome (IBS). As a result, camostat mesilate has no effect on visceral sensitivity, colonic motility or serum cytokines compared with placebo in IBS patients.
Amount: ¥4,420,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Investigator: Motoyori KANAZAWA
Institution: Tohoku University
Field: Medicine
Funded outputs count: 20
Funder award ID: 20590693
OpenAlex ID: G195668985
Management and Pathophysiology of Functional Gastrointestinal Disorders
2012 · Shin Fukudo, Hiroyuki Kuwano, et al. · Digestion · 22
Serotonin Transporter Gene Promoter Polymorphism and Alexithymia
2012 · Michiko Kano, Tomoko Mizuno, et al. · Neuropsychobiology · 42
Neural Substrates of Decision Making as Measured With the Iowa Gambling Task in Men With Alexithymia
2011 · Michiko Kano, Masatoshi Ito, et al. · Psychosomatic Medicine · 34
Lifestyle and psychological factors related to irritable bowel syndrome in nursing and medical school students
2011 · Yukiko Okami, Takako Kato, et al. · Journal of Gastroenterology · 151
Effect of repetitive transcranial magnetic stimulation on rectal function and emotion in humans
2011 · Yuuichi Aizawa, Joe Morishita, et al. · Journal of Gastroenterology · 8
Effect of 5-HT4 receptor agonist mosapride citrate on rectosigmoid sensorimotor function in patients with irritable bowel syndrome
2011 · M. Kanazawa, S. Watanabe, et al. · Neurogastroenterology & Motility · 48
Biopsychosocial Model of Irritable Bowel Syndrome
2011 · Yukari Tanaka, Motoyori Kanazawa, et al. · Journal of Neurogastroenterology and Motility · 307
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Gene, environment, and brain‐gut interactions in irritable bowel syndrome
2011 · Shin Fukudo, Motoyori Kanazawa · Journal of Gastroenterology and Hepatology · 87
Visceral hypersensitivity in irritable bowel syndrome
2011 · Motoyori Kanazawa, Michio Hongo, et al. · Journal of Gastroenterology and Hepatology · 123
The features of adolescent irritable bowel syndrome in Japan
2011 · Yuka Endo, Tomotaka Shoji, et al. · Journal of Gastroenterology and Hepatology · 52
Efficacy and safety of oral lubiprostone in constipated patients with or without irritable bowel syndrome: a randomized, placebo-controlled and dose-finding study
2011 · S. Fukudo, M. Hongo, et al. · Neurogastroenterology & Motility · 93
Effect of rikkunshito on gastric sensorimotor function under distention
2010 · M. Shiratori, T. Shoji, et al. · Neurogastroenterology & Motility · 43
Role of microbial fermentation products in irritable bowel syndrome
2010 · S. Fukudo, Y. Umesaki, et al. · Neurogastroenterology & Motility · 2
Differential responding of autonomic function to histamine H1 antagonism in irritable bowel syndrome
2010 · T. Hattori, S. Watanabe, et al. · Neurogastroenterology & Motility · 13
Effect of Autogenic Training on General Improvement in Patients with Irritable Bowel Syndrome: A Randomized Controlled Trial
2009 · Masae Shinozaki, Motoyori Kanazawa, et al. · Applied Psychophysiology and Biofeedback · 68
Site-specific differences in central processing of visceral stimuli from the rectum and the descending colon in men
2009 · m. kanazawa, t. hamaguchi, et al. · Neurogastroenterology & Motility · 9
Changes in salivary physiological stress markers induced by muscle stretching in patients with irritable bowel syndrome
2008 · Toyohiro Hamaguchi, Shin Fukudo, et al. · BioPsychoSocial Medicine · 19
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Contributions of Pain Sensitivity and Colonic Motility to IBS Symptom Severity and Predominant Bowel Habits
2008 · Motoyori Kanazawa, Olafur S. Palsson, et al. · The American Journal of Gastroenterology · 156
Small intestinal bacterial overgrowth in irritable bowel syndrome: association with colon motility, bowel symptoms, and psychological distress
2008 · M. Grover, M. Kanazawa, et al. · Neurogastroenterology & Motility · 111
事物認識とその表現形成の徹底化を通して独創的で『ねばり強い』思考能力を育成する : 幼・小・中等15年間にわたる教育課程の研究開発 : 幼稚園における取り組み : 幼稚園における研究の方法(3) : エピソード記録の作成(1)
2007 · 幼年教育研究会 奈良女子大学文学部附属幼稚園 · 研究紀要
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