Head and Neck squamous cell carcinoma radiation response modulation by HPV
Description: Project Narrative Head and neck squamous cell carcinomas associated with human papillomavirus (HPV) infection are rapidly increasing in global incidence, often present at an advanced stage, are commonly treated with radiation and chemotherapy, and generally show an improved prognosis; nevertheless, selection of optimal therapy remains ill defined. This proposal investigates molecular mechanisms of treatment response with a goal to identify novel means of radiosensitization, the relationship between epidermal growth factor receptor (EGFR) signaling and radiosensitivity, and potential novel mechanisms of radiosensitization. The ultimate objective is to design rationale combinations of radiation and chemotherapy to further improve outcome and/or decrease treatment toxicity.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R00
Start date: 2013-03-01
End date: 2017-02-28
Investigator: RANDALL J. KIMPLE
Institution: UNIVERSITY OF WISCONSIN-MADISON
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 33
Funder award ID: R00CA160639
OpenAlex ID: G1986077458