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Gene Transcripts and Proteomics in Families with Platelet Hyperaggregation

Description: PUBLIC HEALTH RELEVANCE: Platelets in the circulating blood can stick together (aggregate), clot and cause heart attack or stroke. We will develop a better understanding of the process through sequencing genes that are transcribed in platelets and comparing the patterns of gene expression in people whose platelets have very high levels of aggregation to those with normal aggregation. The results will lead to better and more specific treatments to reduce platelet aggregation in people who are at risk for complications of arterial occlusions.

Funder: National Heart, Lung, and Blood Institute

Funding type: research

Funder scheme: R01

Start date: 2014-04-01

End date: 2019-03-31

Investigator: LEWIS C BECKER

Institution: JOHNS HOPKINS UNIVERSITY

Topic: Platelet Disorders and Treatments

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

Funded outputs count: 5