Investigation of oral mucosal inflammatory disease developing mechanism via Toll-like receptor
Description: Oral keratinocytes and fibroblasts may augment host defense and inflammatory responses against oral microorganisms invasion. However, it remains unclear whether oral keratinocytes and fibroblasts produce specific inflammatory proteins in response to Pathogen-associated molecular patterns (PAMPS) and associated with oral mucosal inflammatory diseases. Our results showed that oral keratinocytes and fibroblasts expressed mRNA of TLRs 1-10. IL-8 and CXCL10 production from oral keratinocytes and fibroblasts was induced by treatment with various TLR agonisits. These findings suggest that recognition of microorganism-derived pathogen in oral keratinocytes and fibroblasts by TLR may have important role to orchestrate host immune responses and promoting hyper/hypo reactions related to oral inflammatory diseases via production of various chemokines.
Amount: ¥4,160,000
Funding type: fellowship
Funder scheme: Grant-in-Aid for Young Scientists (B)
Investigator: Hiromi NISHI (lead)
Institution: Hiroshima University
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Funded outputs count: 3
Funder award ID: 23792346
OpenAlex ID: G204708698