Unique Domain Features of GRK2 and Roles in Cardiovascular Disease
Description: PROJECT NARRATIVE Heart disease is the leading cause of death in Americans, resulting from co-morbid conditions including chronic hypertension and heart attack that culminate in the development of heart failure (HF). While significant advances have been made in stabilizing and relieving symptoms of HF patients, the underlying mechanisms of cardiac remodeling are still a major focus of research efforts towards therapeutic development. This proposal will investigate whether the N-terminal peptides of GRK2, βARKrgs and βARKnt, can act therapeutically to reverse cardiac remodeling after injury, and will use these peptides as tools to determine whether select activities can be assigned to specific domains within GRK2, including distinct protein-proteins interactions and regulation that will expand our understanding of cardiovascular signaling pathways and may highlight new therapeutic targets for the treatment of human HF.
Funding type: research
Funder scheme: R00
Start date: 2016-08-15
End date: 2022-03-31
Investigator: SARAH MARIE SCHUMACHER
Institution: CLEVELAND CLINIC LERNER COM-CWRU
Subfield: Molecular Biology
Domain: Life Sciences
Funded outputs count: 6
Funder award ID: R00HL132882
OpenAlex ID: G2052214624