Award

272111

Funder: Canadian Institutes of Health Research

Funded outputs count: 10

Funder award ID: 272111

OpenAlex ID: G2052260643

Development of 2-(5,6,7-Trifluoro-1H-Indol-3-yl)-quinoline-5-carboxamide as a Potent, Selective, and Orally Available Inhibitor of Human Androgen Receptor Targeting Its Binding Function-3 for the Treatment of Castration-Resistant Prostate Cancer

2021 · Eric Leblanc, Fuqiang Ban, et al. · Journal of Medicinal Chemistry · 13

Drugging the ‘undruggable’. Therapeutic targeting of protein–DNA interactions with the use of computer-aided drug discovery methods

2021 · Mariia Radaeva, Anh-Tien Ton, et al. · Drug Discovery Today · 44

Development of an Androgen Receptor Inhibitor Targeting the N-Terminal Domain of Androgen Receptor for Treatment of Castration Resistant Prostate Cancer

2021 · Fuqiang Ban, Eric Leblanc, et al. · Cancers · 26

Development of Novel Inhibitors Targeting the D-Box of the DNA Binding Domain of Androgen Receptor

2021 · Mariia Radaeva, Fuqiang Ban, et al. · International Journal of Molecular Sciences · 31

Selectively targeting the dimerization interface of human androgen receptor with small-molecules to treat castration-resistant prostate cancer

2018 · Kush Dalal, Fuqiang Ban, et al. · Cancer Letters · 50

Best Practices of Computer-Aided Drug Discovery: Lessons Learned from the Development of a Preclinical Candidate for Prostate Cancer with a New Mechanism of Action

2017 · Fuqiang Ban, Kush Dalal, et al. · Journal of Chemical Information and Modeling · 109

Targeting Binding Function-3 of the Androgen Receptor Blocks Its Co-Chaperone Interactions, Nuclear Translocation, and Activation

2016 · Nada Lallous, Eric Leblanc, et al. · Molecular Cancer Therapeutics · 31

Functional analysis of androgen receptor mutations that confer anti-androgen resistance identified in circulating cell-free DNA from prostate cancer patients

2016 · Nada Lallous, Stanislav V. Volik, et al. · Genome biology · 208

Orphan nuclear receptors as drug targets for the treatment of prostate and breast cancers

2014 · Mani Roshan-Moniri, Michael Hsing, et al. · Cancer Treatment Reviews · 42

Discovery of Small-Molecule Inhibitors Selectively Targeting the DNA-Binding Domain of the Human Androgen Receptor

2014 · Huifang Li, Fuqiang Ban, et al. · Journal of Medicinal Chemistry · 120