Basic research for investigation of novel oncogenic mechanism by TLS-CHOP chimeric oncoprotein and its clinical application
Description: The TLS-CHOP fusion gene derived from chromosomal translocation is myxoid liposarcoma-specific oncogene. However, its oncogenesis mechanism and functions in tumor cells are still unclear. In this study, we have revealed that TLS-CHOP represses an anticancer cytokine MDA-7/IL-24 expression, and represses miR-486 that targets a tumor cell growth and metastasis activator PAI-1 In addition, a novel molecular pathway that induces expression of a tumorigenesis-related protein PRG4 has been suggested.
Amount: ¥3,900,000
Funding type: research
Funder scheme: Grant-in-Aid for Scientific Research (C)
Investigator: Kosuke OIKAWA (lead)
Institution: Wakayama Medical University
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Funded outputs count: 6
Funder award ID: 22590367
OpenAlex ID: G2118945587