Nanoscale Coordination Polymers Co-deliver Chemotherapeutics and siRNAs for Efficacious Treatment of Resistant Ovarian Cancer
Description: Project Narrative Resistant ovarian cancers are a terminal disease that cannot be cured with existing therapeutics. We propose to develop robust nanoscale coordination polymers (NCPs) for the co-delivery of chemotherapeutic agents (cisplatin or cisplatin plus gemcitabine) and small interfering RNA (siRNA) cocktails targeting multi-drug resistance (MDR) pathways. By identifying three MDR genes with the highest expression levels in patients' tumors, NCPs carrying chemotherapeutic agents and siRNAs targeting these genes will be designed as personalized therapies for treating these patients with resistant OCa.
Funder: National Institutes of Health
Amount: $415,700
Funding type: research
Funder scheme: R01
Start date: 2018-02-15
End date: 2023-01-31
Investigator: WENBIN LIN
Institution: UNIVERSITY OF CHICAGO
Funded outputs count: 24
Funder award ID: 5r01ca216436-05
OpenAlex ID: G2263293100