Reactivation of breast cancer micrometastases by senescent bone marrow stroma
Description: The proposed study will investigate the induction of senescence in mouse bone marrow stroma by estrogen deprivation in vitro and in vivo as manifested by the secretion of inflammatory cytokines and loss of the capacity to support dormancy of breast cancer cells in an in vitro model and the loss of the capacity to support the dormancy of xenografted human breast cancer cells in the bone marrow microenvironment. Experiments will determine if treatment with estrogen or anti-inflammatory agents can restore the capacity of senescent stroma to support dormancy.
Funder: National Cancer Institute
Funding type: research
Funder scheme: R21
Start date: 2009-06-19
End date: 2012-05-31
Investigator: ROBERT WIEDER (lead)
Institution: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
Subfield: Cell Biology
Domain: Life Sciences
Funded outputs count: 3
Funder award ID: R21CA142537
OpenAlex ID: G2331908676