Award

Taxane Resistance in Breast and Ovarian Cancer Cells

Funder: National Cancer Institute

Funding type: research

Funder scheme: R01

Start date: 2007-08-01

End date: 2013-05-31

Investigator: BRANIMIR I SIKIC

Institution: STANFORD UNIVERSITY

Funded outputs count: 11

Funder award ID: R01CA114037

OpenAlex ID: G2336441735

Continuous 72-h infusion of zosuquidar with chemotherapy in patients with newly diagnosed acute myeloid leukemia stratified for leukemic blast P-glycoprotein phenotype

2024 · John F. Marcelletti, Branimir I. Sikic · Cancer Chemotherapy and Pharmacology · 7

A clinical trial of zosuquidar plus gemtuzumab ozogamicin (GO) in relapsed or refractory acute myeloid leukemia (RR AML): evidence of efficacy based on leukemic blast P-glycoprotein functional phenotype

2023 · John F. Marcelletti, Branimir I. Sikic · Cancer Chemotherapy and Pharmacology · 5

Genomic stability at the coding regions of the multidrug transporter gene ABCB1: insights into the development of alternative drug resistance mechanisms in human leukemia cells

2020 · Kevin G. Chen, George E. Duran, et al. · Cancer Drug Resistance · 3

Evidence of a role for functional heterogeneity in multidrug resistance transporters in clinical trials of P‐glycoprotein modulation in acute myeloid leukemia

2018 · John F. Marcelletti, Branimir I. Sikic, et al. · Cytometry Part B Clinical Cytometry · 16

Cabazitaxel is more active than first-generation taxanes in ABCB1(+) cell lines due to its reduced affinity for P-glycoprotein

2018 · George E. Duran, Volker Derdau, et al. · Cancer Chemotherapy and Pharmacology · 50

Decreased levels of baseline and drug-induced tubulin polymerisation are hallmarks of resistance to taxanes in ovarian cancer cells and are associated with epithelial-to-mesenchymal transition

2017 · George E Duran, Yan C Wang, et al. · British Journal of Cancer · 48

Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1

2016 · Ramin Dubey, Andres M. Lebensohn, et al. · Cancer Research · 41

Single Gene Prognostic Biomarkers in Ovarian Cancer: A Meta-Analysis

2016 · Scooter Willis, Victor M. Villalobos, et al. · PLoS ONE · 123

Clinical trial designs for testing biomarker-based personalized therapies

2012 · Tze Leung Lai, Philip W Lavori, et al. · Clinical Trials · 48

Molecular Pathways: Regulation and Therapeutic Implications of Multidrug Resistance

2012 · Kevin G. Chen, Branimir I. Sikic · Clinical Cancer Research · 197

Expression and Silencing of the Microtubule-Associated Protein Tau in Breast Cancer Cells

2010 · Tatiana Spicakova, Maureen M. O'Brien, et al. · Molecular Cancer Therapeutics · 34