Novel Epigenetic Marks for HIV Latency Entry and Reversal
Description: Project Narrative Transcription of HIV and latency are fundamentally controlled by epigenetic regulations, which is essential for us to take efforts to control HIV reservoirs. This proposal will investigate how a novel and distinct epigenetic molecular signaling –protein crotonylation- directly regulates HIV transcription and latency and how a better understanding of crotonylation signaling can be applied to design specific HDCR inhibitors. Discovery of such a specific HDCR inhibitor may not only help us better understand the catalytic selection of HDCR over HDAC but also can be utilized to improve latency reversal for the cure of HIV in the future.
Funding type: research
Funder scheme: R21
Start date: 2023-07-11
End date: 2025-06-30
Investigator: GUOCHUN JIANG
Institution: UNIV OF NORTH CAROLINA CHAPEL HILL
Funded outputs count: 12
Funder award ID: R21AI167709
OpenAlex ID: G2419711234