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Intraarticular microbial DNA as a novel mediator of osteoarthritis

Description: Project Narrative The proposed research is relevant to public health because a better understanding of how non-genetic environmental risk factors increase the risk for osteoarthritis (OA), and how the gut and/or cartilage microbiome relates to OA, is likely not only to give insights into the causes of OA, but also to give rise to new treatments for OA patients. Thus, this proposal is relevant to the part of the NIH's mission that pertains to fostering fundamental creative discoveries, innovative research strategies, and their applications as a basis for ultimately improving health.
Funding type: research
Funder scheme: R61
Start date: 2020-09-08
End date: 2022-08-31
Investigator: MATLOCK JEFFRIES
Institution: OKLAHOMA MEDICAL RESEARCH FOUNDATION
Subfield: Rheumatology
Field: Medicine
Funded outputs count: 11
Funder award ID: R61AR078075
OpenAlex ID: G2500463564
Borderline acceleration in blood epigenetic age of unclear biological importance in knee osteoarthritis progression: Specimens and data from the Osteoarthritis Initiative and Johnston County Osteoarthritis Project
2025 · Cindy Miranda Brawner, Cassandra Sturdy, et al. · Osteoarthritis and Cartilage · 3
Ketogenic Diet‐Associated Worsening of Osteoarthritis Histologic Secerity, Increased Pain Sensitivity and Gut Microbiome Dysbiosis in Mice
2025 · Gabby Dyson, Montana Barrett, et al. · ACR Open Rheumatology · 4
OA susceptibility in mice is partially mediated by the gut microbiome, is transferrable via microbiome transplantation and is associated with immunophenotype changes
2023 · Emmaline Prinz, Leoni Schlupp, et al. · Annals of the Rheumatic Diseases · 27
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Murine cartilage microbial DNA deposition occurs rapidly following the introduction of a gut microbiome and changes with obesity, aging, and knee osteoarthritis
2023 · Vladislav Izda, Leoni Schlupp, et al. · GeroScience · 13
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Sex‐Linked Discrepancies in C57BL6 /J Mouse Osteoarthritis are Associated With the Gut Microbiome and are Transferrable by Microbiome Transplantation
2023 · Leoni Schlupp, Emmaline Prinz, et al. · Arthritis & Rheumatology · 18
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A Pilot Analysis of Genome‐Wide DNA Methylation Patterns in Mouse Cartilage Reveals Overlapping Epigenetic Signatures of Aging and Osteoarthritis
2022 · Vladislav Izda, Christopher M. Dunn, et al. · ACR Open Rheumatology · 7
Peripheral Blood DNA Methylation–Based Machine Learning Models for Prediction of Knee Osteoarthritis Progression: Biologic Specimens and Data From the Osteoarthritis Initiative and Johnston County Osteoarthritis Project
2022 · Christopher M. Dunn, Cassandra Sturdy, et al. · Arthritis & Rheumatology · 25
The Microbiome in Osteoarthritis: a Narrative Review of Recent Human and Animal Model Literature
2022 · Christopher M. Dunn, Matlock A. Jeffries · Current Rheumatology Reports · 34
DNA methylation and noncoding RNA in OA: Recent findings and methodological advances
2021 · Vladislav Izda, Jake Martin, et al. · Osteoarthritis and Cartilage Open · 10
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Ear wound healing in MRL/MpJ mice is associated with gut microbiome composition and is transferable to non-healer mice via microbiome transplantation
2021 · Cassandra Velasco, Christopher Dunn, et al. · PLoS ONE · 13
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COVID-19: A review of therapeutic strategies and vaccine candidates
2020 · Vladislav Izda, Matlock A. Jeffries, et al. · Clinical Immunology · 274
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