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Microbicidal Proteins from Platelets

Funding type: research
Funder scheme: R01
Start date: 1996-09-15
End date: 2012-02-28
Investigator: MICHAEL R YEAMAN
Institution: LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
Funded outputs count: 40
Funder award ID: R01AI039001
OpenAlex ID: G8229514901
Platelets: at the nexus of antimicrobial defence
2014 · Michael R. Yeaman · Nature Reviews Microbiology · 355
Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus
2013 · George Sakoulas, Cheryl Y. Okumura, et al. · Journal of Molecular Medicine · 141
Emergence of Daptomycin Resistance in Daptomycin-Naïve Rabbits with Methicillin-Resistant Staphylococcus aureus Prosthetic Joint Infection Is Associated with Resistance to Host Defense Cationic Peptides and mprF Polymorphisms
2013 · Nagendra N. Mishra, Soo-Jin Yang, et al. · PLoS ONE · 80
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Role of the LytSR Two-Component Regulatory System in Adaptation to Cationic Antimicrobial Peptides in Staphylococcus aureus
2013 · Soo-Jin Yang, Yan Q. Xiong, et al. · Antimicrobial Agents and Chemotherapy · 46
Bcr1 Functions Downstream of Ssd1 To Mediate Antimicrobial Peptide Resistance in Candida albicans
2013 · Sook-In Jung, Jonathan S. Finkel, et al. · Eukaryotic Cell · 21
Reduced Vancomycin Susceptibility in anIn VitroCatheter-Related Biofilm Model Correlates with Poor Therapeutic Outcomes in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus
2013 · Wessam Abdelhady, Arnold S. Bayer, et al. · Antimicrobial Agents and Chemotherapy · 63
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Peptide antimicrobials: cell wall as a bacterial target
2013 · Nannette Y. Yount, Michael R. Yeaman · Annals of the New York Academy of Sciences · 158
The RpoB H481Y Rifampicin Resistance Mutation and an Active Stringent Response Reduce Virulence and Increase Resistance to Innate Immune Responses in Staphylococcus aureus
2012 · Wei Gao, David R. Cameron, et al. · The Journal of Infectious Diseases · 100
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Reduced Susceptibility to Host-Defense Cationic Peptides and Daptomycin Coemerge in Methicillin-Resistant Staphylococcus aureus From Daptomycin-Naive Bacteremic Patients
2012 · N. N. Mishra, A. S. Bayer, et al. · The Journal of Infectious Diseases · 56
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Efficacy of Synthetic Peptides RP-1 and AA-RP-1 against Leishmania Species In Vitro and In Vivo
2011 · Marie Crisel B. Erfe, Consuelo V. David, et al. · Antimicrobial Agents and Chemotherapy · 26
Context Mediates Antimicrobial Efficacy of Kinocidin Congener Peptide RP-1
2011 · Nannette Y. Yount, Samuel E. Cohen, et al. · PLoS ONE · 20
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The Staphylococcus aureus Two-Component Regulatory System, GraRS, Senses and Confers Resistance to Selected Cationic Antimicrobial Peptides
2011 · Soo-Jin Yang, Arnold S. Bayer, et al. · Infection and Immunity · 154
In Vitro Cross-Resistance to Daptomycin and Host Defense Cationic Antimicrobial Peptides in Clinical Methicillin-Resistant Staphylococcus aureus Isolates
2011 · Nagendra N. Mishra, James McKinnell, et al. · Antimicrobial Agents and Chemotherapy · 134
Correlation of Daptomycin Resistance in a Clinical Staphylococcus aureus Strain with Increased Cell Wall Teichoic Acid Production and d -Alanylation
2011 · Ute Bertsche, Christopher Weidenmaier, et al. · Antimicrobial Agents and Chemotherapy · 127
Emerging Themes and Therapeutic Prospects for Anti-Infective Peptides
2011 · Nannette Y. Yount, Michael R. Yeaman · The Annual Review of Pharmacology and Toxicology · 143
Carotenoid-Related Alteration of Cell Membrane Fluidity Impacts Staphylococcus aureus Susceptibility to Host Defense Peptides
2010 · Nagendra N. Mishra, George Y. Liu, et al. · Antimicrobial Agents and Chemotherapy · 204
Combinatorial Phenotypic Signatures Distinguish Persistent from Resolving Methicillin-Resistant Staphylococcus aureus Bacteremia Isolates
2010 · Kati Seidl, Arnold S. Bayer, et al. · Antimicrobial Agents and Chemotherapy · 68
Lysyl-Phosphatidylglycerol Attenuates Membrane Perturbation Rather than Surface Association of the Cationic Antimicrobial Peptide 6W-RP-1 in a Model Membrane System: Implications for Daptomycin Resistance
2010 · Erin Kilelee, Antje Pokorny, et al. · Antimicrobial Agents and Chemotherapy · 85
Cell Wall Thickening Is Not a Universal Accompaniment of the Daptomycin Nonsusceptibility Phenotype in Staphylococcus aureus : Evidence for Multiple Resistance Mechanisms
2010 · Soo-Jin Yang, Cynthia C. Nast, et al. · Antimicrobial Agents and Chemotherapy · 114
Factors Influencing Time to Vancomycin‐Induced Clearance of Nonendocarditis Methicillin‐ResistantStaphylococcus aureusBacteremia: Role of Platelet Microbicidal Protein Killing andagrGenotypes
2009 · Pamela A. Moise, Alan Forrest, et al. · The Journal of Infectious Diseases · 29
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Platelets in defense against bacterial pathogens
2009 · Michael R. Yeaman · Cellular and Molecular Life Sciences · 304
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Enhanced Expression ofdltABCDIs Associated with the Development of Daptomycin Nonsusceptibility in a Clinical Endocarditis Isolate ofStaphylococcus aureus
2009 · Soo‐Jin Yang, Barry N. Kreiswirth, et al. · The Journal of Infectious Diseases · 135
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Structure of Chemokine-Derived Antimicrobial Peptide Interleukin-8α and Interaction with Detergent Micelles and Oriented Lipid Bilayers
2009 · Sarah Bourbigot, Liam Fardy, et al. · Biochemistry · 17
Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine
2009 · Nannette Y. Yount, Deborah Kupferwasser, et al. · Proceedings of the National Academy of Sciences · 99
Phenotypic and Genotypic Characteristics of Persistent Methicillin‐ResistantStaphylococcus aureusBacteremia In Vitro and in an Experimental Endocarditis Model
2008 · Yan Q. Xiong, Vance G. Fowler, Jr., et al. · The Journal of Infectious Diseases · 118
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