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Oxidative Stress and ERK Signaling in AC-5 KO Longevity

Funding type: research
Funder scheme: R01
Start date: 2006-09-01
End date: 2007-08-31
Investigator: DOROTHY E VATNER
Institution: UNIV OF MED/DENT OF NJ-NJ MEDICAL SCHOOL
Funded outputs count: 11
Funder award ID: R01AG028854
OpenAlex ID: G2599257646
Type 5 Adenylyl Cyclase Increases Oxidative Stress by Transcriptional Regulation of Manganese Superoxide Dismutase via the SIRT1/FoxO3a Pathway
2013 · Lo Lai, Lin Yan, et al. · Circulation · 106
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Modulation of β-adrenergic receptor signaling in heart failure and longevity: targeting adenylyl cyclase type 5
2010 · David Ho, Lin Yan, et al. · Heart Failure Reviews · 68
Adenylyl cyclase type 5 protein expression during cardiac development and stress
2009 · Che-Lin Hu, Rachna Chandra, et al. · American Journal of Physiology-Heart and Circulatory Physiology · 45
Disruption of Type 5 Adenylyl Cyclase Enhances Desensitization of Cyclic Adenosine Monophosphate Signal and Increases Akt Signal With Chronic Catecholamine Stress
2007 · Satoshi Okumura, Dorothy E. Vatner, et al. · Circulation · 123
Sex differences in myocardial infarction and rupture
2007 · Hongyu Qiu, Christophe Depre, et al. · Journal of Molecular and Cellular Cardiology · 11
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Mechanism of Gender-Specific Differences in Aortic Stiffness With Aging in Nonhuman Primates
2007 · Hongyu Qiu, Christophe Depre, et al. · Circulation · 109
Increased apoptosis and myocyte enlargement with decreased cardiac mass; distinctive features of the aging male, but not female, monkey heart
2007 · Xiao-Ping Zhang, Stephen F. Vatner, et al. · Journal of Molecular and Cellular Cardiology · 50
Type 5 Adenylyl Cyclase Disruption Increases Longevity and Protects Against Stress
2007 · Lin Yan, Dorothy E. Vatner, et al. · Cell · 354
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Functional Adenylyl Cyclase Inhibition in Murine Cardiomyocytes by 2′(3′)-O-(N-Methylanthraniloyl)-Guanosine 5′-[γ-Thio]triphosphate
2007 · Dennis Rottlaender, Jan Matthes, et al. · Journal of Pharmacology and Experimental Therapeutics · 20
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Obligatory Role of Cardiac Nerves and α 1 -Adrenergic Receptors for the Second Window of Ischemic Preconditioning in Conscious Pigs
2006 · Raymond K. Kudej, You-Tang Shen, et al. · Circulation Research · 42
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Activation of the Cardiac Proteasome During Pressure Overload Promotes Ventricular Hypertrophy
2006 · Christophe Depre, Qian Wang, et al. · Circulation · 217
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