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P01-AI042288

Funded outputs count: 261
Funder award ID: P01-AI042288
OpenAlex ID: G28051265
Type 1 diabetes SIRPG risk variants increase SIRPγ expression and CD47 loss enhances CD8+ T cell cytotoxicity
2026 · Robert C. Sharp, Matthew E. Brown, et al. · npj Autoimmunity
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Biosensor cell array reveals temporal GABA secretion dynamics from pancreatic islets
2026 · Austin E. Stis, Charles S. Lazimi, et al. · Molecular Metabolism
Unbiased discovery of autoreactive type 1 diabetes T-cell receptors that bind specific hybrid insulin peptides
2026 · Rebecca Elyanow, Amanda Moore, et al. · Research Square · 1
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Beta cell–targeted PD-1 agonist inhibits cell-mediated autoimmunity in pancreas tissue slices
2026 · Matthew W. Becker, Matthew E. Brown, et al. · Science Advances · 2
Manipulation of Alternative Splicing of IKZF1 Elicits Distinct Gene Regulatory Responses in T Cells
2026 · Lucia Pastor, Jeremy R.B. Newman, et al. · Cells
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Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators
2026 · Charles S Lazimi, Austin E Stis, et al. · eLife
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Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators
2026 · Charles S Lazimi, Austin E Stis, et al. · eLife
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TCR2HLA: Calibrated inference of HLA genotypes from TCR repertoires enables identification of immunologically relevant metaclonotypes
2026 · Koshlan Mayer-Blackwell, Anastasia Minervina, et al. · PLoS Computational Biology · 3
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3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes
2025 · Alexandra Rippa, Amanda L. Posgai, et al. · Nature Communications · 20
Human stem cell-derived β cells expressing an optimized CD155 reduce cytotoxic immune cell function for application in type 1 diabetes
2025 · Matthew E. Brown, Jessie M. Barra, et al. · Science Advances · 7
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Inhibition of cell-mediated immunity in type 1 diabetes by beta cell-targeted PD-1 agonists in pancreas tissue slices
2025 · Matthew W. Becker, Matthew Brown, et al. · bioRxiv (Cold Spring Harbor Laboratory)
Beta cell secreted GABA sets appropriate insulin secretion by modulating islet calcium oscillations
2025 · Sandra M. Ferreira, D. Walker Hagan, et al. · Molecular Metabolism · 6
Beta cell dysfunction occurs independently of insulitis in type 1 diabetes pathogenesis
2025 · Mollie K. Huber, Adrienne E. Widener, et al. · Cell Reports · 31
Connecting the Spots: Serial Home C-peptide Measurements Paint an Accurate Picture of Change in β-Cell Function
2025 · Brittany S. Bruggeman, Timothy P. Foster, et al. · Diabetes Care · 1
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Autoimmune origin for immune checkpoint inhibitor-diabetes revealed by deep immune phenotyping of the pancreas
2025 · Zoe Quandt, Arabella Young, et al. · Journal for ImmunoTherapy of Cancer · 3
Protocol for processing and analyzing multiplexed images improves lymphatic cell identification and spatial architecture in human tissue
2025 · Justin A. Smith, Drew T. Bloss, et al. · STAR Protocols · 1
Loss of Insulin-Positive Cell Clusters Precedes the Decrease in Islet Frequency and β-Cell Area in Type 1 Diabetes
2025 · Denise M. Drotar, Giovanni J.A. Vazquez Ramos, et al. · Diabetes · 19
Type 1 Diabetes Autoantibodies in Acute, Recurrent Acute, and Chronic Pancreatitis
2025 · Clive H. Wasserfall, Chris E. Forsmark, et al. · Diabetes · 4
Increased inflammation as well as decreased endoplasmic reticulum stress and translation differentiate pancreatic islets from donors with pre-symptomatic stage 1 type 1 diabetes and non-diabetic donors
2025 · Adam C. Swensen, Paul D. Piehowski, et al. · Diabetologia · 6
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Immune perturbations in human pancreas lymphatic tissues prior to and after type 1 diabetes onset
2025 · Gregory J. Golden, Vincent H. Wu, et al. · Nature Communications · 22
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Efficient transduction of pancreas tissue slices with genetically encoded calcium integrators
2025 · Charles S. Lazimi, Austin E. Stis, et al. · bioRxiv (Cold Spring Harbor Laboratory) · 1
Emerging Immunotherapies for Disease Modification of Type 1 Diabetes
2025 · Timothy P. Foster, Brittany S. Bruggeman, et al. · Drugs · 17
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Characterizing cell-type spatial relationships across length scales in spatially resolved omics data
2025 · Rafael dos Santos Peixoto, Brendan F. Miller, et al. · Nature Communications · 14
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Serological markers of exocrine pancreatic function are differentially informative for distinguishing individuals progressing to type 1 diabetes
2025 · MacKenzie D Williams, Catherine Ramsey Grace, et al. · BMJ Open Diabetes Research & Care
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Sex‐specific cytokine, chemokine, and growth factor signatures in T1D patients and progressors
2024 · Khyati Girdhar, Keiichiro Mine, et al. · The FASEB Journal · 6
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