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Inducible Macrophage Specific Gene Expression in Diseases

Description: Narrative Macrophages play a key role in the pathogenesis of multiple chronic inflammatory diseases. In this proposal, we will characterize a newly developed conditional, macrophage-specific mouse model, where Cre recombinase is regulated by the scavenger receptor A promoter. Our model will allow to knockout genes of interest only in macrophages and at any stage of the disease. The major goal of our proposal is to generate a mouse model that will allow researchers to specifically and conditionally knockout genes of interest in macrophages during chronic inflammatory diseases. This model will be a highly valuable model, allowing researchers to precisely assess the roles and functions of genes expressed by macrophages during chronic inflammatory diseases. In addition, we propose to cross this model into the atherosclerosis- prone Apoe knockout model, to allow examination of macrophage genes in this important vascular disease. We will also examine the consequences of the absence of macrophage tissue inhibitor of metalloproteinases-3 in lung injury.

Funder: National Heart, Lung, and Blood Institute

Funding type: research

Funder scheme: RC1

Start date: 2009-09-30

End date: 2012-08-31

Investigator: JEANINE M D'ARMIENTO

Institution: COLUMBIA UNIVERSITY HEALTH SCIENCES

Topic: Immune cells in cancer

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Funded outputs count: 4