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Dynamics of the FOXO transcription factor network

Description: Project Narrative FOXO protein activity has been linked to extended lifespan, decreased cancer risk and cancer cell death in response to targeted chemotherapy treatment. This study will provide novel insights into how FOXO proteins sense and respond to both targeted chemotherapy treatment and other types of cellular stress. Our ultimate goal is to use this information to manipulate FOXO activity to increase the efficacy of targeted therapies.
Funding type: research
Funder scheme: R01
Start date: 2019-01-01
End date: 2023-12-31
Investigator: ANDREW LUTHER PAEK
Institution: UNIVERSITY OF ARIZONA
Funded outputs count: 7
Funder award ID: R01GM130864
OpenAlex ID: G2981734026
A dose-dependent switch in translation capacity controls the transcription factor response to H 2 O 2 stress
2026 · Chance Parkinson, Woody March-Steinman, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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Nuclear EGFR in breast cancer suppresses NK cell recruitment and cytotoxicity
2024 · Angelica Escoto, Ryan Hecksel, et al. · Oncogene · 7
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Temporal coordination of the transcription factor response to H2O2 stress
2024 · Elizabeth Jose, Woody March-Steinman, et al. · Nature Communications · 46
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Temporal Coordination of the Transcription Factor Response to H 2 O 2 stress
2023 · Elizabeth Jose, Woody March-Steinman, et al. · bioRxiv (Cold Spring Harbor Laboratory)
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FOXO nuclear shuttling dynamics are stimulus-dependent and correspond with cell fate
2023 · Kathleen A. Lasick, Elizabeth Jose, et al. · Molecular Biology of the Cell · 26
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Live-cell imaging in human colonic monolayers reveals ERK waves limit the stem cell compartment to maintain epithelial homeostasis
2022 · Kelvin W Pond, Julia M Morris, et al. · eLife · 26
Designing combination therapies with modeling chaperoned machine learning
2019 · Yin Zhang, Julie M. Huynh, et al. · PLoS Computational Biology · 14
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